DUX4 Monoclonal Antibody (P2B1), APC | Invitrogen MA5-45265 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DUX4 Monoclonal Antibody (P2B1), APC

catalog :

MA5-45265

quantity :

100 ug

price :

US 444.00

clonality :

monoclonal

host :

mouse

conjugate :

APC

clone name :

P2B1

The same clone is also sold as:

Rockland Immunochemicals: 209-301-F23

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

DUX4 Monoclonal Antibody (P2B1), APC

Catalog # :

MA5-45265

Quantity :

100 ug

Price :

US 444.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse

Applications :

Immunocytochemistry: 1:1,000, Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000

Species :

Human, Mouse

Clone :

P2B1

Isotype :

IgG1

Storage :

4 C

Description :

DUX4 (also known as Double homeobox 4) is the leading candidate causative gene for facioscapulohumeral dystrophy (FSHD), a degenerative skeletal muscle disease and one of the most common muscular dystrophies. FSHD is caused by the deletion of a subset of D4Z4 macrosatellite repeats on chromosome 4. Each repeat contains a retrogene encoding the double-homeobox factor DUX4. DUX4 expression is epigenetically suppressed in differentiated tissues and the residual DUX4 transcripts are spliced to remove the carboxyterminal domain that has been associated with cell toxicity. In FSHD individuals, the expression of the full-length DUX4 transcript is not completely suppressed in skeletal muscle, and possibly other differentiated tissues, and results in a small percentage of cells expressing relatively abundant amounts of the full-length DUX4 mRNA and protein.

Immunogen :

C-terminal 76 amino acids of DUX4 with glutathione-s-transferase (gst) tag

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:1,000, Immunohistochemistry: Assay-dependent, Western Blot: 1:1,000

Aliases :

AW822073; double homeobox; double homeobox 4; double homeobox 4-like; double homeobox B-like 1; double homeobox protein 10; Double homeobox protein 4; double homeobox protein 4/10; Dux; DUX10; Dux4; DUX4L; Duxbl; Duxbl1; EG664783; homeobox protein; RGD1311053