PKN2 Recombinant Rabbit Monoclonal Antibody (JE62-44) | Invitrogen MA5-44818 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

PKN2 Recombinant Rabbit Monoclonal Antibody (JE62-44)

catalog :

MA5-44818

quantity :

100 uL

price :

US 470.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

JE62-44

reactivity :

human, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

PKN2 Recombinant Rabbit Monoclonal Antibody (JE62-44)

Catalog # :

MA5-44818

Quantity :

100 uL

Price :

US 470.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

Immunocytochemistry: 1:50, Immunohistochemistry (Paraffin): 1:100-1:500, Western Blot: 1:500-1:2,000

Species :

Human, Rat

Clone :

JE62-44

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

PKN2 (PRK2), a close relative of the PKCs, is a regulator of mitosis and exit from cytokinesis. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication.

Immunogen :

Recombinant protein within human PKN2 aa 885-984/984.

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:50, Immunohistochemistry (Paraffin): 1:100-1:500, Western Blot: 1:500-1:2,000

Aliases :

6030436C20Rik; AI507382; cardiolipin-activated protein kinase Pak2; p140 kinase; PAK2; Pak-2; PKN gamma; PKN2; PRK2; PRKCL2; PRO2042; protease-activated kinase 2; protein kinase C-like 2; protein kinase N2; protein-kinase C-related kinase 2; RP5-905H16.1; serine/threonine kinase 7; serine/threonine-protein kinase N2; serine/threonine-protein kinase N2; serine/threonine-protein kinase N2-like; si:ch211-83f14.1; Stk7; wu:fa97c07