IDH1 (R132H) Recombinant Rabbit Monoclonal Antibody (RM390), Biotin

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

IDH1 (R132H) Recombinant Rabbit Monoclonal Antibody (RM390), Biotin

catalog :

MA5-44584

quantity :

50 uL

price :

US 389.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

biotin

clone name :

RM390

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

IDH1 (R132H) Recombinant Rabbit Monoclonal Antibody (RM390), Biotin

Catalog # :

MA5-44584

Quantity :

50 uL

Price :

US 389.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: Assay-dependent

Species :

Human

Clone :

RM390

Isotype :

IgG

Storage :

-20 C

Description :

Isocitrate dehydrogenases such as IDH1 catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. This product is specific for IDH1 (mutant R132H).

Immunogen :

A peptide corresponding to human (R132H mutant specific). The immunogen range is a synthetic peptide within amino acids 180-280 of human IDH1 with R132H mutant.

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: Assay-dependent

Aliases :

Cytosolic NADP-isocitrate dehydrogenase; epididymis luminal protein 216; epididymis secretory protein Li 26; HEL-216; HEL-S-26; IDCD; IDH; IDH1; IDH1-mutant; IDP; IDPC; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase [NADP] cytoplasmic; isocitrate dehydrogenase 1 (NADP+); isocitrate dehydrogenase 1 (NADP+), soluble; NADP(+)-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; oxalosuccinate decarboxylase; PICD