SETX Recombinant Rabbit Monoclonal Antibody (BLR050F) | Invitrogen MA5-44293 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SETX Recombinant Rabbit Monoclonal Antibody (BLR050F)

catalog :

MA5-44293

quantity :

100 uL

price :

US 369.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

BLR050F

The same clone is also sold as:

Abcam: ab243904

reactivity :

human

application :

western blot, immunoprecipitation

product information

Product Type :

Antibody

Product Name :

SETX Recombinant Rabbit Monoclonal Antibody (BLR050F)

Catalog # :

MA5-44293

Quantity :

100 uL

Price :

US 369.00

Clonality :

Recombinant Monoclonal

Purity :

purified

Host :

Rabbit

Reactivity :

Human

Applications :

Immunoprecipitation: 6 uL/1 mg lysate, Western Blot: 1:1,000

Species :

Human

Clone :

BLR050F

Isotype :

IgG

Storage :

4 C

Description :

Probable RNA/DNA helicase involved in diverse aspects of RNA metabolism and genomic integrity. Plays a role in transcription regulation by its ability to modulate RNA Polymerase II (Pol II) binding to chromatin and through its interaction with proteins involved in transcription (PubMed:19515850, PubMed:21700224). Contributes to the mRNA splicing efficiency and splice site selection (PubMed:19515850). Required for the resolution of R-loop RNA-DNA hybrid formation at G-rich pause sites located downstream of the poly(A) site, allowing XRN2 recruitment and XRN2-mediated degradation of the downstream cleaved RNA and hence efficient RNA polymerase II (RNAp II) transcription termination (PubMed:19515850, PubMed:21700224, PubMed:26700805). Required for the 3' transcriptional termination of PER1 and CRY2, thus playing an important role in the circadian rhythm regulation. Involved in DNA double-strand breaks damage response generated by oxidative stress (PubMed:17562789). In association with RRP45, targets the RNA exosome complex to sites of transcription-induced DNA damage (PubMed:24105744). Plays a role in the development and maturation of germ cells: essential for male meiosis, acting at the interface of transcription and meiotic recombination, and in the process of gene silencing during meiotic sex chromosome inactivation (MSCI). May be involved in telomeric stability through the regulation of telomere repeat-containing RNA (TERRA) transcription (PubMed:21112256). Plays a role in neurite outgrowth in hippocampal cells through FGF8-activated signaling pathways. Inhibits retinoic acid-induced apoptosis (PubMed:21576111).

Immunogen :

Peptide representing a region between residues 900 and 950 of human Senataxin.

Format :

Liquid

Applications w/Dilutions :

Immunoprecipitation: 6 uL/1 mg lysate, Western Blot: 1:1,000

Aliases :

A130090N03; A930037J23Rik; Als4; amyotrophic lateral sclerosis 4 homolog; amyotrophic lateral sclerosis 4 protein; Amyotrophic lateral sclerosis 4 protein homolog; AOA2; AW060766; bA479K20.2; DEAxQ-box helicase; KIAA0625; mKIAA0625; Probable helicase senataxin; RGD1565575; SCAR1; Sen1; SEN1 homolog; senataxin; Setx; tRNA splicing endonuclease regulator 1