Azurocidin Recombinant Rabbit Monoclonal Antibody (421) | Invitrogen MA5-43368 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Azurocidin Recombinant Rabbit Monoclonal Antibody (421)

catalog :

MA5-43368

quantity :

50 uL

price :

US 242.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

421

The same clone is also sold as:

Sino Biological: 10660-R421

reactivity :

human

product information

Product Type :

Antibody

Product Name :

Azurocidin Recombinant Rabbit Monoclonal Antibody (421)

Catalog # :

MA5-43368

Quantity :

50 uL

Price :

US 242.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: 1:250-1:2,000

Species :

Human

Clone :

421

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Azurocidin, also called heparin-binding protein (HBP), is an inactive homolog of serine proteinases residing in granulocytes. Initially it was thought to have only activity against gram-negative bacteria. Later it was also found to act against gram-positive bacteria and C. albicans. Azurocidin is considered a family member of polymorphonuclear leukocytes- derived antimicrobial proteins like defensins, LL-37 and lysozyme. Azurocidin has been recognized as a player in the activation and modulation of the immune response and may act to alarm the immune system. The cationic domain at one side of the protein is essential for its antimicrobial activity. It is stored in azurophil granules as well as secretory granules and as a result partly released at early stage of extravasation. Azurocidin is involved in chemotaxis and activation of monocytes, cytokine release and phagocytosis leading to more efficient bacterial clearance. The primary targeted environment of azurocidin are cells in the bloodstream, that is the endothelial lining, and the extravascular surroundings. The interaction of azurocidin with leucocytes is mediated via beta 2-intergrins. High plasma levels of azurocidin might help with the identification of patients which are at risk in developing sepsis.

Immunogen :

Recombinant Human Azurocidin/CAP37 Protein.

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:250-1:2,000

Aliases :

AZAMP; AZU; AZU1; Azurocidin; azurocidin 1; CAP37; cationic antimicrobial protein 37; cationic antimicrobial protein CAP37; HBP; Heparin-binding protein; hHBP; HUMAZUR; NAZC; neutrophil azurocidin; pHBP