Mesothelin Recombinant Rabbit Monoclonal Antibody (5R9H8) | Invitrogen MA5-42914 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Mesothelin Recombinant Rabbit Monoclonal Antibody (5R9H8)

catalog :

MA5-42914

quantity :

100 uL

price :

US 470.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

5R9H8

reactivity :

human, rat

application :

western blot, ELISA, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

Mesothelin Recombinant Rabbit Monoclonal Antibody (5R9H8)

Catalog # :

MA5-42914

Quantity :

100 uL

Price :

US 470.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity Chromatography

Host :

Rabbit

Reactivity :

Human, Rat

Applications :

ELISA: 1 ug/mL, Immunocytochemistry: 1:100-1:400, Western Blot: 1:1,000-1:2,000

Species :

Human, Rat

Clone :

5R9H8

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Originally identified as a differentiation antigen of mesotheliomas, ovarian cystadenocarcinomas, and pancreatic adenocarcinomas, Mesothelin is a glycosylphosphatidylinositol (GPI)-anchored, cell-surface glycoprotein predominantly secreted by cells of the mesothelium. Although Mesothelin is expressed at restricted levels by normal mesothelial cells of the pleural,pericardial, and peritoneal membranes, aberrant expression has been documented in the aforementioned cancers, as well as in endometriod uterine adenocarcinomas and squamous cell carcinomas of the esophagus, stomach, lung, and cervix. Proteolytic cleavage of Mesothelin yields a soluble, polypeptide fragment designated megakaryocyte potentiating factor (MPF) based on its ability to stimulate megakaryocyte colony-forming activity of murine interleukin-3 in murine bone marrow cell cultures. Originally isolated from the HPC-Y5 pancreatic cell line, MPF has been suggested to play a role in the proliferation and differentiation of megakaryoctyes, and the regulation of resultant platelet production. While the biological functions of both Mesothelin and MPF remain speculative, high-levels of expression in cancerous tissues compared to limited distribution in normal tissues strongly suggests their involvement in tumorigenesis. Both have been demonstrated to promote tumor cell proliferation, migration,anchorage-independent growth, and tumor progression; demonstrating their involvement in heterotypic cell adhesion and the metastatic spread of cancer.

Immunogen :

A synthetic peptide corresponding to a sequence within amino acids 500-600 of human Mesothelin (Q13421).

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Immunocytochemistry: 1:100-1:400, Western Blot: 1:1,000-1:2,000

Aliases :

CAK1; CAK1 antigen; megakaryocyte potentiating factor; Megakaryocyte-potentiating factor; Mes; Mesothelin; Mesothelin, cleaved form; MPF; MSLN; Pre-pro-megakaryocyte-potentiating factor; SMR; SMRP; soluble MPF mesothelin related protein