CD3e/CD3g Recombinant Rabbit Monoclonal Antibody (4F5G4) | Invitrogen MA5-42744 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD3e/CD3g Recombinant Rabbit Monoclonal Antibody (4F5G4)

catalog :

MA5-42744

quantity :

100 uL

price :

US 470.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

4F5G4

reactivity :

human

application :

western blot, ELISA, flow cytometry

product information

Product Type :

Antibody

Product Name :

CD3e/CD3g Recombinant Rabbit Monoclonal Antibody (4F5G4)

Catalog # :

MA5-42744

Quantity :

100 uL

Price :

US 470.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity Chromatography

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: 1 ug/mL, Flow Cytometry: 1:500-1:1,000, Western Blot: 1:1,000-1:5,000

Species :

Human

Clone :

4F5G4

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

The CD3 subunit complex which is crucial in transducing antigen-recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules and this association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation. The CD3 antigen is present on 68-82% of normal peripheral blood lymphocytes, 65-85% of thymocytes and Purkinje cells in the cerebellum. It is never expressed on B or NK cells. Decreased percentages of T lymphocytes may be observed in some autoimmune diseases. The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. Defects in the CD3 gene are associated with CD3 immunodeficiency.

Immunogen :

Recombinant fusion protein containing a sequence corresponding to amino acids 1-207(CD3E)& 1-182(CD3G) of human CD3 epsilon&CD3 gamma Heterodimer

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Flow Cytometry: 1:500-1:1,000, Western Blot: 1:1,000-1:5,000