CCR2 Recombinant Rabbit Monoclonal Antibody (SN707) | Invitrogen MA5-41175 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CCR2 Recombinant Rabbit Monoclonal Antibody (SN707)

catalog :

MA5-41175

quantity :

100 uL

price :

US 470.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SN707

The same clone is also sold as:

Novus Biologicals: NBP2-67700

reactivity :

human, mouse

application :

western blot, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Reference
Taylor X, Clark I, Fitzgerald G, Oluoch H, Hole J, DeMattos R, et al. Amyloid-β (Aβ) immunotherapy induced microhemorrhages are associated with activated perivascular macrophages and peripheral monocyte recruitment in Alzheimer's disease mice. Mol Neurodegener. 2023;18:59 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CCR2 Recombinant Rabbit Monoclonal Antibody (SN707)

Catalog # :

MA5-41175

Quantity :

100 uL

Price :

US 470.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1:500-1:1,000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:1,000

Species :

Human, Mouse

Clone :

SN707

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CCR2, a chemokine receptor, is a regulator of monocyte/macrophage traffickings and is upregulated in response to inflammation. Resistance to HIV-1 infection or delayed progression to AIDS may be linked to CCR2 polymorphisms. The ligand for CCR2 is monocyte chemoattractant protein (MCP-1), a chemokine produced by endothelial cells, smooth muscle cells, and macrophages. Activation of monocytes by MCP-1 may mediate the monocytic infiltration of tissues in atherosclerosis and other inflammatory disorders including rheumatoid arthritis, alveolitis, and tumor infiltration. Two isoforms are produced by alternative splicing. CCR2 has been reported to be expressed in a wide variety of tissues, including blood, brain, heart, kidney, liver, lung, ovary, pancreas, spinal cord, spleen, thymus, and vessel. Increased expression of CCR2 has been documented in CD3+ lymphocytes in rheumatoid arthritis. ESTs have been isolated from liver/spleen and prostate libraries.

Immunogen :

Synthetic peptide within N-terminal human CCR2

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:500-1:1,000, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:1,000

Aliases :

C-C chemokine receptor type 2; C-C CHEMOKINE RECEPTOR TYPE 2 (C-C CKR-2) (CC-CKR-2) (CCR-2) (CCR2) (JE/FIC RECEPTOR) (MCP-1 RECEPTOR); C-C CKR-2; C-C motif chemokine receptor 2; Cc-ckr2; CC-CKR-2; Ccr2; CCR-2; Ccr2a; CCR2B; CD192; CD192 antigen; chemoattractant protein-1 receptor; chemokine (C-C motif) receptor 2; chemokine (C-C) receptor 2; chemokine receptor CCR2; Ckr2; Ckr2a; Ckr2b; CMKBR2; hCG_14621; JE/FIC receptor; Mcp1 receptor; MCP-1 receptor; Mcp1r; MCP-1-R; MIP-1 alphaR; mJe-r; Monocyte chemoattractant protein 1 receptor; monocyte chemotactic protein 1 receptor