Nicastrin Recombinant Rabbit Monoclonal Antibody (002), PE | Invitrogen MA5-41000 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Nicastrin Recombinant Rabbit Monoclonal Antibody (002), PE

catalog :

MA5-41000

quantity :

100 Tests

price :

US 492.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

clone name :

2

The same clone is also sold as:

Abcam: ab275620, ab275621

reactivity :

human

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

Nicastrin Recombinant Rabbit Monoclonal Antibody (002), PE

Catalog # :

MA5-41000

Quantity :

100 Tests

Price :

US 492.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

Isotype :

IgG

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.

Immunogen :

Recombinant Human Nicastrin/NCSTN protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

9430068N19Rik; AA727311; anterior pharynx-defective 2; Aph2; ATAG1874; D1Dau13e; Kiaa0253; mKIAA0253; NCSTN; Nct; Nicastrin; OTTHUMP00000031840; UNQ1874/PRO4317