FSTL1 Recombinant Rabbit Monoclonal Antibody (009), FITC | Invitrogen MA5-40946 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

FSTL1 Recombinant Rabbit Monoclonal Antibody (009), FITC

catalog :

MA5-40946

quantity :

100 Tests

price :

US 489.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

FITC

clone name :

9

The same clone is also sold as:

Abcam: ab275694

reactivity :

human

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

FSTL1 Recombinant Rabbit Monoclonal Antibody (009), FITC

Catalog # :

MA5-40946

Quantity :

100 Tests

Price :

US 489.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: Assay-Dependent

Species :

Human

Clone :

Isotype :

IgG

Storage :

4 C, store in dark, DO NOT FREEZE!

Description :

Follistatin-like protein 1 (FSTL1) is a widely-expressed, extracellular glycoprotein that is homologously grouped into the osteonectin (BM-40/SPARC) family of secreted proteins based on its possession of both a follistatin-like and extracellular calcium-binding domain. Initially identified as a TGF-beta-inducible protein in a cloned mouse osteoblast cell line, FSTL1 has since been implicated in an array of cell-type-specific functions, such as the regulation of proliferation, differentiation, apoptosis and migration, as well as a number of biological processes, including embryonic development, inflammatory response, angiogenesis, tumorigenesis, and immune disease pathogenesis. Highly conserved across mammalian species and widely expressed in human tissues, FSTL1 can be upregulated through signaling mediators of the innate immune system,such as TLR4 agonists and the arthritogenic cytokine IL-1beta via NFkappaB pathways, to stimulate the expression and secretion of pro-inflammatory cytokines, including TNF-alpha, IL-1beta, IL-6 and IL-8. While cells of mesenchymal lineage are capable of FSTL1 production, FSTL1 expression is notably absent from cells of hematopoietic lineage under normal physiological conditions. Macrophages and monocytes are, however, capable of taking up FSTL1 at sites of inflammation where FSTL1 stimulation can cause the expression of caspase-1 and its resultant enzymatic cleavage of active IL-1beta from pro-IL-1beta. Whereas the overexpression of FSTL1 has been noted as a substantial contributor to the progression of immune diseases like rheumatoid arthritis (RA) and osteoarthritis (OA), diminished FSTL1 serum levels have been identified as playing a significant part in both ovarian and endometrial carcinogenesis, where it directly affects cell proliferation, migration and invasion.

Immunogen :

Recombinant Human FSTL1 Protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Assay-Dependent

Aliases :

AI316791; AW107808; FLJ50214; FLJ52277; follistatin like 1; follistatin-like 1; follistatin-like protein 1; Follistatin-related protein 1; FRP; FSL1; Fstl; FSTL1; MIR198; OCC1; OCC-1; TGF-beta-inducible protein TSC-36; tsc36; TSC-36