This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
IL-33R (ST2) Recombinant Rabbit Monoclonal Antibody (ST2IL33R-H2)
catalog :
MA5-37452
quantity :
20 uL
price :
US 329.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
ST2IL33R-H2

The same clone is also sold as:
reactivity :
human
application :
flow cytometry
product information
Product Type :
Antibody
Product Name :
IL-33R (ST2) Recombinant Rabbit Monoclonal Antibody (ST2IL33R-H2)
Catalog # :
MA5-37452
Quantity :
20 uL
Price :
US 329.00
Clonality :
Recombinant Monoclonal
Purity :
Protein A/G
Host :
Rabbit
Reactivity :
Human
Applications :
Flow Cytometry: 5 uL/1x10^6 cells
Species :
Human
Clone :
ST2IL33R-H2
Isotype :
IgG, kappa
Storage :
-20 C
Description :
IL-33R, also known as ST2, is a receptor for IL-33. It is a member of the IL-1 receptor family of innate receptors. Its extracellular domain consists of 3 Ig-like domains that directly interact with its co-receptor IL-1RAcP, and the ligand alarmin, IL-33. IL-33 ligation results in the association of IL-33R complex with its adaptor proteins MyD88, IRAK1, IRAK4 and TRAF6, and activation of the NF-kB, and MAPK pathways. This, in turn, instigates the release of chemokines and cytokines such as IL-5, IL-6, IL-8, and IL-13. Two most common isoforms of IL-33R that result from alternative splicing are ST2L – the membrane bound form, and ST2S – the soluble form. The membrane bound form can be released from the cell surface by proteolytic cleavage. The soluble forms have been suggested to act as decoys dampening the IL-33 signaling. IL-33R is primarily expressed by mast cells, basophils, and eosinophils. In mouse, IL-33R expression has been shown on ILC2 and Th2 cells. IL-33R signaling has been implicated in the number of immune conditions, including allergies, arthritis, atherosclerosis and sepsis.
Immunogen :
human recombinant ST2-Fc.
Format :
Liquid
Applications w/Dilutions :
Flow Cytometry: 5 uL/1x10^6 cells
Aliases :
DER4; Fit1; Fit-1; Fos-responsive gene 1 protein; growth stimulation-expressed; homolog of mouse growth stimulation-expressed; IL-1 R4; IL1RL1; IL-1RL1; IL33R; IL-33R; interleukin 1 receptor like 1; interleukin 1 receptor-like 1; interleukin 1 receptor-related protein; Interleukin1 receptor like 1; interleukin-1 receptor-like 1; Interleukin-33 receptor alpha chain; Ly84; lymphocyte antigen 84; Protein ST2; Protein T1; sIL 33R; soluble IL 33 Receptor; soluble IL 33R; St2; ST2L; St2-rs1; ST2V; Ste2; T1; T1/ST2
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA