Phospho-SHP-1 (Tyr536) Recombinant Rabbit Monoclonal Antibody (Shp1Y536-2A7)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-SHP-1 (Tyr536) Recombinant Rabbit Monoclonal Antibody (Shp1Y536-2A7)

catalog :

MA5-37374

quantity :

20 uL

price :

US 329.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

Shp1Y536-2A7

reactivity :

human

application :

flow cytometry

citations: 1

Reference
Pugh J, Guethlein L, Parham P. Abundant CpG-sequences in human genomes inhibit KIR3DL2-expressing NK cells. Peerj. 2021;9:e12258 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-SHP-1 (Tyr536) Recombinant Rabbit Monoclonal Antibody (Shp1Y536-2A7)

Catalog # :

MA5-37374

Quantity :

20 uL

Price :

US 329.00

Clonality :

Recombinant Monoclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Human

Applications :

Flow Cytometry: 1-1,000 ng/mL

Species :

Human

Clone :

Shp1Y536-2A7

Isotype :

IgG, kappa

Storage :

-20 C

Description :

SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells. The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain. SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways. In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth. Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation. Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.

Immunogen :

A synthetic phospho-peptide corresponding to residues surrounding Tyr536 of human phospho Shp1.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-1,000 ng/mL

Aliases :

70Z-SHP; EC 3.1.3.48; hcp; Hcph; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; me; motheaten; protein tyrosine phosphatase, non-receptor type 6; protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; Ptp1C; PTP-1C; Ptph6; PTPN6; PTPTY-42; SH2 phosphatase 1; SHP1; Shp-1; SHP-1L; SH-PTP1; Tyrosine-protein phosphatase non-receptor type 6