Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (chk1S317-F10), FITC

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (chk1S317-F10), FITC

catalog :

MA5-37282

quantity :

10 Tests

price :

US 197.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

FITC

clone name :

Chk1S317-F10

reactivity :

human, mouse

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

Phospho-Chk1 (Ser317) Recombinant Rabbit Monoclonal Antibody (chk1S317-F10), FITC

Catalog # :

MA5-37282

Quantity :

10 Tests

Price :

US 197.00

Clonality :

Recombinant Monoclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 5 uL/1x10^6 cells

Species :

Human, Mouse

Clone :

chk1S317-F10

Isotype :

IgG, kappa

Storage :

4 C, store in dark

Description :

CHEK1 (CHK1) is a serine/threonine protein kinase involved in preventing replication when DNA integrity is compromised. CHK1 is a key mediator in the DNA damage-induced checkpoint network. CHK1 is an evolutionarily conserved protein kinase that functions to ensure genomic integrity upon genotoxic stress. When the G2 or S checkpoint is abrogated by the inhibition of CHK1, p53-deficient cancer cells undergo mitotic catastrophe and eventually apoptosis, whereas normal cells are still arrested in the G1 phase. Thus, CHK1 inhibitors can preferentially potentiate the efficacy of DNA damaging agents in cancer cells, and Chk1 is an attractive therapeutic target for cancer treatment, especially since approximately 50% of all human cancers are p53-deficient.

Immunogen :

A synthetic phospho-peptide corresponding to residues surrounding Ser317 of human phospho Chk1.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL/1x10^6 cells

Aliases :

C85740; Cell cycle checkpoint kinase; checkpoint kinase 1; checkpoint kinase 1 homolog; checkpoint kinase-1; Checkpoint, S. pombe, homolog of, 1; CHEK1; CHK1; CHK1 checkpoint homolog; Chk1-S; homolog of Chk1-S; HRD1 Protein; rad27; rad27 homolog; serine/threonine protein kinase CHK1; serine/threonine-protein kinase Chk1; Synoviolin; YBR1742; YBR274W