Phospho-PTEN (Ser380) Recombinant Rabbit Monoclonal Antibody (PTENS380-NA9), PE

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-PTEN (Ser380) Recombinant Rabbit Monoclonal Antibody (PTENS380-NA9), PE

catalog :

MA5-37051

quantity :

100 Tests

price :

US 484.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

clone name :

PTENS380-NA9

The same clone is also sold as:

Abcam: ab278749, ab278748, ab278587

reactivity :

human, mouse

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

Phospho-PTEN (Ser380) Recombinant Rabbit Monoclonal Antibody (PTENS380-NA9), PE

Catalog # :

MA5-37051

Quantity :

100 Tests

Price :

US 484.00

Clonality :

Recombinant Monoclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 5 uL/1x10^6 cells

Species :

Human, Mouse

Clone :

PTENS380-NA9

Isotype :

IgG, kappa

Storage :

4 C

Description :

PTEN was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The PTEN gene is a phosphatidylinositol-3, 4, 5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. PTEN negatively regulates intracellular levels of phosphatidylinositol-3, 4, 5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. PTEN plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. Also, PTEN may be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form of PTEN induces less tumor suppressive ability.

Immunogen :

A synthetic phospho peptide corresponding to residues surrounding Ser380 of human phospho PTEN.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL/1x10^6 cells

Aliases :

10q23del; 2310035O07Rik; A130070J02Rik; AI463227; B430203M17Rik; BZS; CWS1; DEC; GLM2; homolog of human mutated in multiple advanced cancers; MHAM; mitochondrial phosphatase and tensin protein alpha; mitochondrial PTENalpha; Mmac; MMAC1; MMAC1 phosphatase and tensin homolog deleted on chromosome 10; mutated in multiple advanced cancers 1; Phosphatase and tensin homolog; phosphatase and tensin homolog (mutated in multiple advanced cancers 1); phosphatase and tensin homolog deleted on chromosome ten; phosphatase and tensin-like protein; phosphatidylinositol 3; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol-3; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; protein tyrosine phosphatase and tensin-like protein; PTEN; pten tumor suppressor; PTEN1; TEP1