Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), APC

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), APC

catalog :

MA5-36992

quantity :

10 Tests

price :

US 197.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

APC

clone name :

CREBS133-4D11

The same clone is also sold as:

Abcam: ab278703, ab278578, ab278739

reactivity :

human, mouse

application :

flow cytometry

citations: 1

Reference
Fan H, Xia S, Xiang J, Li Y, Ross M, Lim S, et al. Trans-vaccenic acid reprograms CD8+ T cells and anti-tumour immunity. Nature. 2023;623:1034-1043 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-CREB (Ser133) Recombinant Rabbit Monoclonal Antibody (CREBS133-4D11), APC

Catalog # :

MA5-36992

Quantity :

10 Tests

Price :

US 197.00

Clonality :

Recombinant Monoclonal

Purity :

Protein A/G

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 5 uL/1x10^6 cells

Species :

Human, Mouse

Clone :

CREBS133-4D11

Isotype :

IgG, kappa

Storage :

4 C

Description :

CREB (Cyclic AMP response element binding protein) is a 43 kDa basic/leucine zipper transcription factor that binds the cyclic AMP response element (CRE) and activates transcription in response to a variety of extracellular signals including neurotransmitters, hormones, membrane depolarization, and growth and neurotrophic factors. Activation of CREB is dependent upon the phosphorylation of serine 133. Phosphorylation of CREB occurs via p44/42 MAP kinase and p90RSK, and via p38 MAP kinase and MSK1. Although CREB will bind DNA independent of its phosphorylation state, only the phosphorylated form is competent as a transcription factor. CREB binding protein (CBP), a transcriptional coactivator that directly interacts with CREB, binds to CREB in the region of serine 133. CREB is involved in different cellular processes including the synchronization of circadian rhythmicity, differentiation of adipose cells, and learning and memory. In humans, the gene is located on the q arm of chromosome 2. Diseases associated with CREB dysfunction include Alzheimer’s Disease, histiocytoma and soft tissue melanoma.

Immunogen :

A synthetic phospho-peptide corresponding to residues surrounding Ser133 of human phospho CREB.

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 5 uL/1x10^6 cells

Aliases :

2310001E10Rik; 3526402H21Rik; active transcription factor CREB; AV083133; cAMP response element binding protein 1; cAMP responsive element binding protein 1; cAMP-response element-binding protein-1; cAMP-responsive element-binding protein 1; CREB; CREB1; Creb-1; cyclic adenosine 3',5'-monophosphate response element-binding protein CREB; cyclic AMP-responsive element-binding protein 1; htCREB; MGC9284; OTTHUMP00000206661; OTTHUMP00000206662; OTTHUMP00000206667; transactivator protein; Y protein