EGFRvIII Recombinant Rabbit Monoclonal Antibody (RM419) | Invitrogen MA5-36216 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

EGFRvIII Recombinant Rabbit Monoclonal Antibody (RM419)

catalog :

MA5-36216

quantity :

100 uL

price :

US 480.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM419

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

EGFRvIII Recombinant Rabbit Monoclonal Antibody (RM419)

Catalog # :

MA5-36216

Quantity :

100 uL

Price :

US 480.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: 1:100-1:1,000, Flow Cytometry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:1,000-1:2,000

Species :

Human

Clone :

RM419

Isotype :

IgG

Storage :

-20 C

Description :

EGFRvIII is included in receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, amphiregulin, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Isoform 2 may act as an antagonist of EGF action.

Immunogen :

A peptide corresponding to epidermal growth factor receptor variant III (EGFRvIII) (aa 1-100).

Format :

Liquid

Applications w/Dilutions :

ELISA: 1:100-1:1,000, Flow Cytometry: 1:10-1:100, Immunohistochemistry (Paraffin): 1:100-1:200, Western Blot: 1:1,000-1:2,000

Aliases :

6720426O10Rik; 9030024J15Rik; A830025P08Rik; AI552599; avian erythroblastic leukemia viral (v-erbB) oncogene homolog; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog; cell growth inhibiting protein 40; cell proliferation-inducing protein 61; Cntn5; CNTN6; contactin 5; contactin 6; contactin-5; Contactin-6; EGFR; EGFR-related peptide; epidermal growth factor receptor; Epidermal growth factor receptor formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); epidermal growth factor receptor, formerly avian erythroblastic leukemia viral (v-erbB) oncogene homolog (Erbb1); Erbb; ERBB1; ErbB-1; erb-b2 receptor tyrosine kinase 1; Errb1; Errp; Gm507; HER1; hNB-2; HNB-2s; hNB-3; mENA; mNB-3; Nb-2; NB3; NB-3; neural adhesion molecule; neural recognition molecule NB-2; Neural recognition molecule NB-3; NISBD2; PIG61; Proto-oncogene c-ErbB-1; receptor tyrosine-protein kinase erbB-1; wa2; wa-2; Wa5; waved 2