DBF4 Recombinant Rabbit Monoclonal Antibody (JE52-50) | Invitrogen MA5-36154 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DBF4 Recombinant Rabbit Monoclonal Antibody (JE52-50)

catalog :

MA5-36154

quantity :

100 uL

price :

US 474.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

JE52-50

reactivity :

human, mouse

application :

western blot, flow cytometry

product information

Product Type :

Antibody

Product Name :

DBF4 Recombinant Rabbit Monoclonal Antibody (JE52-50)

Catalog # :

MA5-36154

Quantity :

100 uL

Price :

US 474.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1:50-1:100, Western Blot: 1:500-1:2,000

Species :

Human, Mouse

Clone :

JE52-50

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Activator of S phase kinase (ASK, DBF4) is a novel regulatory subunit of the human Cdc7 kinase complex that plays a pivotal role in G1/S cell cycle transition in mammalian cells. The increase in Cdc7 kinase activity at the G1/S boundary is at least partly accounted for by the elevated expression of ASK in late G1. ASK interacts with replication origins in vivo, suggesting that Cdc7 may trigger S phase by directly activating the replication initiation complexes assembled at the origins. Human ASK protein levels are regulated during the cell cycle with a pattern that matches that of human Cdc7 protein kinase activity. Human Cdc7-ASK kinase is directly involved in regulating the initiation of DNA replication by targeting MCM2 protein in mammalian cells. Nuclear localization and chromatin binding of endogenous huCdc7 and GFP-ASK is presumably imported into nuclei through its two nuclear localization signals at telophase, it may require additional signals for chromatin binding, the level of which increases at late G1 ohase. A functional link may exist between menin, a tumor suppressor protein mutated in multiple endocrine neoplasia type I (MEN1), and ASK in the regulation of cell proliferation.

Immunogen :

Recombinant protein within Human DBF4 aa 1-107

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50-1:100, Western Blot: 1:500-1:2,000

Aliases :

AA545217; Activator of S phase kinase; ASK; CHIF; chiffon homolog A; Dbf4; DBF4 homolog; DBF4 homolog (S. cerevisiae); DBF4 zinc finger; DBF4 zinc finger A; DBF4A; DBF4-type zinc finger-containing protein 1; MuDBF4; Protein DBF4 homolog A; RGD1305854; ZDBF1; zinc finger, DBF-type containing 1