SETD7 Recombinant Rabbit Monoclonal Antibody (ARC1483) | Invitrogen MA5-35782 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SETD7 Recombinant Rabbit Monoclonal Antibody (ARC1483)

catalog :

MA5-35782

quantity :

100 uL

price :

US 474.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

ARC1483

reactivity :

human, mouse, rat

application :

western blot, ELISA

citations: 1

Reference
Bichmann M, Prat Oriol N, Ercan Herbst E, Sch xf6 ndorf D, Gomez Ramos B, Schw xe4 rzler V, et al. SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease. Mol Neurodegener. 2021;16:46 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SETD7 Recombinant Rabbit Monoclonal Antibody (ARC1483)

Catalog # :

MA5-35782

Quantity :

100 uL

Price :

US 474.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity Chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: 1 ug/mL, Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Rat

Clone :

ARC1483

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. [UniProt]

Immunogen :

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SETD7 (Q8WTS6)

Format :

Liquid

Applications w/Dilutions :

ELISA: 1 ug/mL, Western Blot: 1:500-1:1,000

Aliases :

1600028F23Rik; FLJ21193; H3-K4 methyltransferase; H3-K4-HMTase; H3-K4-HMTase SETD7; H3K4MT; Histone H3-K4 methyltransferase SETD7; histone H3-lysine 4-specific methyltransferase; histone-lysine N-methyltransferase SETD7; Kiaa1717; KMT7; lysine N-methyltransferase 7; mKIAA1717; OTTHUMP00000220049; SET domain containing (lysine methyltransferase) 7; SET domain containing 7, histone lysine methyltransferase; SET domain containing 7, lysine methyltransferase; SET domain containing lysine methyltransferase 7; SET domain-containing protein 7; Set7; Set7/9; SET9; Setd7