TDP-43 Recombinant Rabbit Monoclonal Antibody (ARC0492) | Invitrogen MA5-35273 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TDP-43 Recombinant Rabbit Monoclonal Antibody (ARC0492)

catalog :

MA5-35273

quantity :

100 uL

price :

US 474.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

ARC0492

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 1

Reference
Candia R, Cohen L, Morozova V, Corbo C, Alonso A. Importin-Mediated Pathological Tau Nuclear Translocation Causes Disruption of the Nuclear Lamina, TDP-43 Mislocalization and Cell Death. Front Mol Neurosci. 2022;15:888420 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TDP-43 Recombinant Rabbit Monoclonal Antibody (ARC0492)

Catalog # :

MA5-35273

Quantity :

100 uL

Price :

US 474.00

Clonality :

Recombinant Monoclonal

Purity :

Affinity Chromatography

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ChIP Assay: 5 ug antibody for 10 ug-15 ug of Chromatin, ELISA: 1 ug/mL, Immunocytochemistry: 1:200-1:2,000, Immunohistochemistry (Paraffin): 1:200-1:2,000, Immunoprecipitation: 0.5 ug-4 ug antibody for 400 ug-600 ug extracts of, Western Blot: 1:1,000-1:6,000

Species :

Human, Mouse, Rat

Clone :

ARC0492

Isotype :

IgG

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

TDP43 was first identified as a novel cellular protein that binds to HIV-1 virus TAR DNA sequence motifs and acts a transcriptional repressor to the HIV-1 LTR. Later experiments revealed that TDP43 also regulates the splicing of exon 9 of the cystic fibrosis transmembrane conductance regular (CFTR), most likely through the association with the UG repeats at the 3'e; splice site. A hyperphosphorylated, ubiquitinated, and cleaved form of TDP43 known as pathologic TDP43 is the major disease protein in ubiquitin-positive, tau-, and alpha-synuclein-negative frontotemporal dementia (FLTD-U). TDP43 is not related to TRBP1, and RNA binding protein that binds HIV-1 TAR RNA sequences.

Immunogen :

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human TDP-43/TARDB (Q13148)

Format :

Liquid

Applications w/Dilutions :

Aliases :

1190002A23Rik; ALS10; C85084; hypothetical protein; OTTHUMP00000002171; OTTHUMP00000002173; RCJMB04_5g9; RP4-635E18.2; TAR DNA binding protein; TAR DNA binding protein L homeolog; TAR DNA-binding protein 43; TAR DNA-binding protein-43; tardbp; tardbp.L; Tdp43; TDP-43; wu:fb77f02; wu:fc52g10; XELAEV_18035188mg