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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Phospho-alpha Synuclein (Ser129) Recombinant Rabbit Monoclonal Antibody (JB22-44)
catalog :
MA5-34671
quantity :
100 µL
price :
US 464
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
JB22-44
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Invitrogen product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 1e
Zhao J, Lu W, Ren Y, Fu Y, Martens Y, Shue F, et al. Apolipoprotein E regulates lipid metabolism and α-synuclein pathology in human iPSC-derived cerebral organoids. Acta Neuropathol. 2021;142:807-825 pubmed publisher
product information
Product Type :
Antibody
Product Name :
Phospho-alpha Synuclein (Ser129) Recombinant Rabbit Monoclonal Antibody (JB22-44)
Catalog # :
MA5-34671
Quantity :
100 µL
Price :
US 464
Clonality :
Recombinant Monoclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human
Applications :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500
Species :
Human
Clone :
JB22-44
Isotype :
IgG
Storage :
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Description :
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. These proteins are abundant in the brain and play a role in regulating synaptic transmission and membrane trafficking. Alpha- and beta-synuclein have been shown to selectively inhibit phospholipase D2, suggesting that they may also be involved in signaling pathways. Defects in the SNCA gene, which encodes alpha-synuclein, have been implicated in the pathogenesis of Parkinson's disease. Additionally, alpha-synuclein peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Multiple alternatively spliced transcripts encoding different isoforms have been identified for this gene. Diseases associated with SNCA include Parkinson Disease 1, Autosomal Dominant and Dementia, Lewy Body.
Immunogen :
Synthetic peptide within Human Phospho-alpha Synuclein (S129) aa 91-140
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:500
Aliases :
Alpha synuclein; alphaSYN; alpha-synuclein; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; Non-A4 component of amyloid precursor; PARK1; PARK4; PD1; Snca; Syn; synuclein alpha; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor)
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA