HPV Type 16 E6 Monoclonal Antibody (HPV-13E2) | Invitrogen MA5-33324 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HPV Type 16 E6 Monoclonal Antibody (HPV-13E2)

catalog :

MA5-33324

quantity :

100 ug

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HPV-13E2

reactivity :

human

application :

immunohistochemistry, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

HPV Type 16 E6 Monoclonal Antibody (HPV-13E2)

Catalog # :

MA5-33324

Quantity :

100 ug

Price :

US 480.00

Clonality :

Monoclonal

Purity :

Affinity chromatography

Host :

Mouse

Reactivity :

Virus

Applications :

ELISA: Assay-dependent, Immunohistochemistry (Frozen): 1-2 ug/ml

Species :

Virus

Clone :

HPV-13E2

Isotype :

IgG1, kappa

Storage :

4 C, do not freeze

Description :

Plays a major role in the induction and maintenance of cellular transformation. Acts mainly as an oncoprotein by stimulating the destruction of many host cell key regulatory proteins. E6 associates with host E6-AP ubiquitin-protein ligase, and inactivates tumor suppressors TP53 and TP73 by targeting them to the 26S proteasome for degradation. In turn, DNA damage and chromosomal instabilities increase and lead to cell proliferation and cancer development. The complex E6/E6P targets several other substrates to degradation via the proteasome including host NFX1-91, a repressor of human telomerase reverse transcriptase (hTERT). The resulting increased expression of hTERT prevents the shortening of telomere length leading to cell immortalization. Other cellular targets including Bak, Fas-associated death domain-containing protein (FADD) and procaspase 8, are degraded by E6/E6AP causing inhibition of apoptosis. E6 also inhibits immune response by interacting with host IRF3 and TYK2. These interactions prevent IRF3 transcriptional activities and inhibit TYK2-mediated JAK-STAT activation by interferon alpha resulting in inhibition of the interferon signaling pathway.

Immunogen :

HPV-16 E6 synthetic peptide

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Immunohistochemistry (Frozen): 1-2 ug/ml

Aliases :

Human Papillomavirus; Human Papillomavirus 16