Bcl-2 Recombinant Rabbit Monoclonal Antibody (2C6) | Invitrogen MA5-33119 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Bcl-2 Recombinant Rabbit Monoclonal Antibody (2C6)

catalog :

MA5-33119

quantity :

100 uL

price :

US 491.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

2C6

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

Bcl-2 Recombinant Rabbit Monoclonal Antibody (2C6)

Catalog # :

MA5-33119

Quantity :

100 uL

Price :

US 491.00

Clonality :

Recombinant Monoclonal

Purity :

Antigen affinity chromatography, Protein G

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:5,000

Species :

Human, Mouse, Rat

Clone :

2C6

Isotype :

IgG

Storage :

-20 C or -80 C if preferred

Description :

BCL-2 is a key regulator of apoptosis that functions to either inhibit or promote cell death. The BCL-2 family members are also characterized by dimerizing to further modulate apoptosis. Bag1, for example, has been found to form a heterodimer with BCL-2 resulting in the enhancement of the anti-apoptotic effect of BCL-2. Bax and Bak have been shown to play a critical role in cytochrome c release from mitochondria and thus initiate apoptosis. Bax exerts a pro-apoptotic rather than an anti-apoptotic effect on cells. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. In most follicular lymphomas, neoplastic germinal centers express high levels of BCL-2 alpha protein, whereas the normal or hyperplastic germinal centers are negative. Two transcript variants of BCL-2, produced by alternate splicing, differ in their C-terminal ends. The overexpression of BCL-2 has been linked to human cancers such as B-cell lymphoma and prostate cancer.

Immunogen :

Synthesized Bcl-2 Antibody (48-81aa)

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-Dependent, Flow Cytometry: Assay-Dependent, Immunohistochemistry (Paraffin): 1:50-1:500, Western Blot: 1:500-1:5,000

Aliases :

apoptosis regulator Bcl-2; AW986256; B cell leukemia/lymphoma 2; B cell lymphoma 2 associated oncogene; B-cell CLL/lymphoma 2; B-cell leukemia/lymphoma 2; Bcl 2; BCL2; bcl-2; BCL2 apoptosis regulator; Bcl-2 protein; BCL2, apoptosis regulator; Bcl2-like protein; C430015F12Rik; D630044D05Rik; D830018M01Rik; OTTHUMP00000163680; PPP1R50; protein phosphatase 1, regulatory subunit 50