AKT1 (E17K Mutant) Recombinant Rabbit Monoclonal Antibody (RM336)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

AKT1 (E17K Mutant) Recombinant Rabbit Monoclonal Antibody (RM336)

catalog :

MA5-33069

quantity :

50 ug

price :

US 491.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM336

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Product Type :

Antibody

Product Name :

AKT1 (E17K Mutant) Recombinant Rabbit Monoclonal Antibody (RM336)

Catalog # :

MA5-33069

Quantity :

50 ug

Price :

US 491.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human

Applications :

ELISA: 0.05-0.5 ug/mL, Immunocytochemistry: 0.2-1 ug/mL, Immunohistochemistry: 0.2-1 ug/mL, Western Blot: 0.1-0.5 ug/mL

Species :

Human

Clone :

RM336

Isotype :

IgG

Storage :

-20 C

Description :

The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene.

Immunogen :

A peptide corresponding to Akt E17K mutant.

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.05-0.5 ug/mL, Immunocytochemistry: 0.2-1 ug/mL, Immunohistochemistry: 0.2-1 ug/mL, Western Blot: 0.1-0.5 ug/mL

Aliases :

AKT; AKT serine/threonine kinase 1; AKT1; AKT1m; CWS6; PKB; PKB alpha; PKB-ALPHA; PRKBA; Protein kinase B; Protein kinase B alpha; proto-oncogene c-Akt; RAC; rac protein kinase alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1