Phospho-gamma-H2AX (Ser139) Recombinant Rabbit Monoclonal Antibody (RM224)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Phospho-gamma-H2AX (Ser139) Recombinant Rabbit Monoclonal Antibody (RM224)

catalog :

MA5-33062

quantity :

100 ug

price :

US 480.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

RM224

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry

citations: 4

Reference
Nelson T, Xu Y. Sting and p53 DNA repair pathways are compromised in Alzheimer's disease. Sci Rep. 2023;13:8304 pubmed publisher
Lipskaia L, Maisonnasse P, Fouillade C, Sencio V, Pascal Q, Flaman J, et al. Evidence That SARS-CoV-2 Induces Lung Cell Senescence: Potential Impact on COVID-19 Lung Disease. Am J Respir Cell Mol Biol. 2022;66:107-111 pubmed publisher
Hua Y, Wang Y, Kang X, Xu F, Han Z, Zhang C, et al. A multifunctional AIE gold cluster-based theranostic system: tumor-targeted imaging and Fenton reaction-assisted enhanced radiotherapy. J Nanobiotechnology. 2021;19:438 pubmed publisher
Moyer S, Wasylishen A, Qi Y, Fowlkes N, Su X, Lozano G. p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo. Proc Natl Acad Sci U S A. 2020;117:23663-23673 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Phospho-gamma-H2AX (Ser139) Recombinant Rabbit Monoclonal Antibody (RM224)

Catalog # :

MA5-33062

Quantity :

100 ug

Price :

US 480.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

All, Human, Mouse, Rat

Applications :

ELISA: 0.2-1 ug/mL, Immunocytochemistry: 0.5-2 ug/mL, Luminex: 0.1-1 ug/mL, Western Blot: 0.5-2 ug/mL

Species :

All, Human, Mouse, Rat

Clone :

RM224

Isotype :

IgG

Storage :

-20 C

Description :

H2AX is a variant of the H2A protein family and is a component of the histone octomer in nucleosomes. H2AX is phosphorylated by kinases such as ataxia telangiectasia mutated (ATM) and ATM-Rad3-related (ATR) in the PI3K pathway. Gamma-H2AX is the first step in recruiting and localizing DNA repair proteins. DSBs can be induced by mechanisms such as ionizing radiation or cytotoxic agents and subsequently, gamma-H2AX foci quickly form. These foci represent the DSBs in a 1:1 manner and can be used as a biomarker for damage. The visualization of gamma-H2AX by can allow the assessment of DNA damage, related DNA damage proteins and DNA repair. Gamma-H2AX has applications in the detection of genomic damage caused by cytotoxic chemical agents and environmental and physical damage.

Immunogen :

A phospho-peptide corresponding to Phospho-Histone H2AX (Ser139).

Format :

Liquid

Applications w/Dilutions :

ELISA: 0.2-1 ug/mL, Immunocytochemistry: 0.5-2 ug/mL, Luminex: 0.1-1 ug/mL, Western Blot: 0.5-2 ug/mL

Aliases :

gamma H2A X; gamma H2A.X; gamma-H2A.X; gh2ax