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company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
GFAP Recombinant Rabbit Monoclonal Antibody (RM246)
catalog :
MA5-33059
quantity :
100 µL
price :
US 446.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
RM246
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - free floating section
more info or order :
Invitrogen product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; mouse; 1:400; loading ...; fig 5c
Liang B, Thapa R, Zhang G, Moffitt C, Zhang Y, Johnston A, et al. Aberrant neural activity in prefrontal pyramidal neurons lacking TDP-43 precedes neuron loss. Prog Neurobiol. 2022;215:102297 pubmed publisher
product information
Product Type :
Antibody
Product Name :
GFAP Recombinant Rabbit Monoclonal Antibody (RM246)
Catalog # :
MA5-33059
Quantity :
100 µL
Price :
US 446.00
Clonality :
Recombinant Monoclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human, Mouse
Applications :
Immunohistochemistry (Paraffin): 1:200-1:500, Western Blot: 1:1,000-1:3,000
Species :
Human, Mouse
Clone :
RM246
Isotype :
IgG
Storage :
-20°C
Description :
GFAP (Glial fibrillary acidic protein) is a member of the class III intermediate filament protein family. GFAP is heavily and specifically expressed in astrocytes and certain astroglia of the central nervous system, in satellite cells of peripheral ganglia, and in non-myelinating Schwann cells of peripheral nerves. In addition, neural stem cells strongly express GFAP. Antibodies to GFAP are very useful as markers of astrocytic cells. In addition, many types of brain tumor, presumably derived from astrocytic cells, heavily express GFAP. GFAP is also found in the lens epithelium, Kupffer cells of the liver, in some cells in salivary tumors and has been reported in erythrocytes. GFAP is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.
Immunogen :
A peptide corresponding to the N-terminus of human GFAP.
Format :
Liquid
Applications w/Dilutions :
Immunohistochemistry (Paraffin): 1:200-1:500, Western Blot: 1:1,000-1:3,000
Aliases :
6330404F12Rik; 65 kDa glutamic acid decarboxylase; AI836096; ALXDRD; Astrocyte or Intermediate Filament Protein; cb345; class III intermediate filament protein; etID36982.3; FLJ45472; GAD(65); Gad2; Gad-2; GAD65; GAD-65; GFAP; GFAP epsilon; gfap protein; gfapl; glial fibrillary acidic protein; Glial Fibrillary Acidic Protein (GFAP); glial fibrillary acidic protein alpha; glutamate decarboxylase 2; Glutamate decarboxylase 65 kDa isoform; glutamic acid decarboxylase 2; I79_011607; intermediate filament; intermediate filament protein; intermediate filament protein; GFAP; Unknown (protein for MGC:139638); wu:fb34h11; wu:fk42c12; xx:af506734; zgc:110485; zGFAP; intermediate filament protein; zrf-1 antigen
more info or order :
Invitrogen product webpage
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA