Tyrosine Hydroxylase Monoclonal Antibody (TH-16) | Invitrogen MA5-32984 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Tyrosine Hydroxylase Monoclonal Antibody (TH-16)

catalog :

MA5-32984

quantity :

100 ug

price :

US 464.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

TH-16

reactivity :

human, mouse, rat, domestic rabbit

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

Tyrosine Hydroxylase Monoclonal Antibody (TH-16)

Catalog # :

MA5-32984

Quantity :

100 ug

Price :

US 464.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Human, Mouse, Rabbit, Rat

Applications :

Immunohistochemistry (Frozen): 0.5-1 ug/mL, Immunohistochemistry (Paraffin): 0.5-1 ug/mL, Western Blot: 0.25-0.5 ug/mL

Species :

Human, Mouse, Rabbit, Rat

Clone :

TH-16

Isotype :

IgG1

Storage :

-20 C

Description :

Tyrosine hydroxylase (TH) is an enzyme involved in the synthesis of catecholamine neurotransmitters dopamine, epinephrine, and norepinephrine. In all species, catecholamine synthesis is regulated by the interaction of TH with a cofactor, tetrahydrobiopterin (BH4). BH4 binds to the TH catalytic domain, resulting in enzymatic activity. Unlike TH in non-primate species, four human TH mRNA splice variants (hTH1-hTH4) have been isolated. These variants are identical in their catalytic domain, but differ in their N-terminal, regulatory domains. TH is also responsible for the conversion of L-tyrosine to L-dopa. TH plays a key role in the physiology of adrenergic neurons. The role of TH in the synthesis of catecholamine neurotransmitters suggests a correlation between the enzyme and a number of neuropathogenic diseases including: Parkinson's disease, schizophrenia, Segawa syndrome, and dystonia, as well as a variety of cardiovascular diseases.

Immunogen :

Rat tyrosine hydroxylase (TH).

Format :

Lyophilized

Applications w/Dilutions :

Immunohistochemistry (Frozen): 0.5-1 ug/mL, Immunohistochemistry (Paraffin): 0.5-1 ug/mL, Western Blot: 0.25-0.5 ug/mL

Aliases :

dystonia 14; DYT14; DYT5b; EC 1.14.16.2; HGNC:11782; Th; TH isoform 3; TH isoform a; th1; TH-4; The; TY3H; TYH; TYH antibody; Tyrosine 3-hydroxylase; tyrosine 3-monooxygenase; tyrosine hydroxylase