TLR2 Recombinant Rabbit Monoclonal Antibody (JM22-41) | Invitrogen MA5-32787 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TLR2 Recombinant Rabbit Monoclonal Antibody (JM22-41)

catalog :

MA5-32787

quantity :

100 uL

price :

US 530.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

JM22-41

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, flow cytometry

more info or order :

Invitrogen product webpage

citations: 7

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 4a	Lagosz Cwik K, Wielento A, Lipska W, Kantorowicz M, Darczuk D, Kaczmarzyk T, et al. hTERT-immortalized gingival fibroblasts respond to cytokines but fail to mimic primary cell responses to Porphyromonas gingivalis. Sci Rep. 2021;11:10770 pubmed publisher
	Wyczanska M, Rohling J, Keller U, Benz M, Kirschning C, Lange Sperandio B. TLR2 mediates renal apoptosis in neonatal mice subjected experimentally to obstructive nephropathy. PLoS ONE. 2023;18:e0294142 pubmed publisher
	Zhu S, Yu Y, Qu M, Qiu Z, Zhang H, Miao C, et al. Neutrophil extracellular traps contribute to immunothrombosis formation via the STING pathway in sepsis-associated lung injury. Cell Death Discov. 2023;9:315 pubmed publisher
	Ilyas Y M, Sahidin I, Jabbar A, Yodha A, Diantini A, Pradipta I, et al. Effect of Immunomodulating Extract and Some Isolates from Etlingera rubroloba A.D. Poulsen Fruits on Diabetic Patients with Tuberculosis. Molecules. 2023;28: pubmed publisher
	Wigger G, Khani D, Ahmed M, Sayegh L, Auld S, Fan X, et al. Alcohol impairs recognition and uptake of Mycobacterium tuberculosis by suppressing toll-like receptor 2 expression. Alcohol Clin Exp Res. 2022;46:2214-2224 pubmed publisher
	Das T, Blasco Conesa M, Korf J, Honarpisheh P, Chapman M, Ganesh B. Bacterial Amyloid Curli Associated Gut Epithelial Neuroendocrine Activation Predominantly Observed in Alzheimer's Disease Mice with Central Amyloid-β Pathology. J Alzheimers Dis. 2022;88:191-205 pubmed publisher
	Li W, Wang T, Huang W, Li F, Quan J, Shi G, et al. Malassezia globosa Activates NLRP3 Inflammasome in Human Sebocytes. J Invest Dermatol. 2022;142:2042-2046.e11 pubmed publisher

product information

Product Type :

Antibody

Product Name :

TLR2 Recombinant Rabbit Monoclonal Antibody (JM22-41)

Catalog # :

MA5-32787

Quantity :

100 uL

Price :

US 530.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1:50-1:100, Immunocytochemistry: 1:50-1:100, Western Blot: 1:500-1:2,000

Species :

Human, Mouse, Rat

Clone :

JM22-41

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

TLR2 is a member of the Toll-like receptor (TLR) family which play a fundamental role in pathogen recognition and activation of innate immunity. TLR proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors such as Protein Kinase C (PKC) alpha/beta and NF-kappa-B. TLR2 can form heterodimers with either TLR1 or TLR6, and as a heterodimer, can recognize a variety of bacterial and mycoplasma lipoproteins respectively. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. The various TLRs exhibit different patterns of expression. TLR2 is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB. TLR2 aids in the recognition of pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Ten human homologs of TLRs (TLR1-10) have been described. TLR2 is expressed in human cells such as tonsils, microglia, lymph nodes, and appendices, activated B-cells in germinal centers. CD14+ monocytes express the highest level of TLR2 followed by CD15+ granulocytes, CD19+ B-cells, and CD3+ T-cells. The expression of TLR2 on different cell types are regulated by different immune response modifiers. For example, LPS, GM-CSF, IL-1, and IL-10 up regulates TLR2 whereas IL-4, IFN-gamma, and TNF down regulate TLR2 expression in monocytes.

Immunogen :

Recombinant protein within Human TLR2 aa 21-588

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50-1:100, Immunocytochemistry: 1:50-1:100, Western Blot: 1:500-1:2,000

Aliases :

CD282; Ly105; TIL4; Tlr2; TLR-2; toll like receptor 2; toll/interleukin-1 receptor-like protein 4; Toll-like receptor; toll-like receptor 2; toll-like receptor 2 variant 1; toll-like receptor 2 variant 2; toll-like-receptor 2, exon 1a_; Toll-like-receptor, exon 1b; Toll-like-receptor, exon 1b_; Toll-like-receptor2, exon 1a

more info or order :

Invitrogen product webpage