HDAC8 Recombinant Rabbit Monoclonal Antibody (SD082-07) | Invitrogen MA5-32411 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HDAC8 Recombinant Rabbit Monoclonal Antibody (SD082-07)

catalog :

MA5-32411

quantity :

100 uL

price :

US 474.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SD082-07

reactivity :

human, mouse, rat

application :

western blot, flow cytometry

product information

Product Type :

Antibody

Product Name :

HDAC8 Recombinant Rabbit Monoclonal Antibody (SD082-07)

Catalog # :

MA5-32411

Quantity :

100 uL

Price :

US 474.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1:50-1:100, Western Blot: 1:1,000-1:2,000

Species :

Human, Mouse, Rat

Clone :

SD082-07

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC8, isolated from human kidney, is a histone deacetylase that shares homology to other HDACs but has different tissue distribution. HDAC8 is localized to the nucleus and plays a role in the development of a broad range of tissues and in the etiology of cancer.

Immunogen :

Synthetic peptide within Human HDAC8 aa 61-110

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50-1:100, Western Blot: 1:1,000-1:2,000

Aliases :

2610007D20Rik; CDA07; CDLS5; HD8; Hdac8; HDACL1; histone deacetylase 8; histone deacetylase-like 1; MRXS6; RGD1562895; RPD3; WTS