ACE2 Recombinant Rabbit Monoclonal Antibody (SN0754) | Invitrogen MA5-32307 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ACE2 Recombinant Rabbit Monoclonal Antibody (SN0754)

catalog :

MA5-32307

quantity :

100 uL

price :

US 470.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SN0754

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation

more info or order :

Invitrogen product webpage

citations: 28

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; human; 0.5 ug/ml; loading ...; fig s3a, s3c	Daniloski Z, Jordan T, Wessels H, Hoagland D, Kasela S, Legut M, et al. Identification of Required Host Factors for SARS-CoV-2 Infection in Human Cells. Cell. 2021;184:92-105.e16 pubmed publisher
western blot; human; 1:500; loading ...; fig 5a, 9a	Manna V, Choi H, Rotoli S, CARADONNA S. The dynamic nature of the coronavirus receptor, angiotensin-converting enzyme 2 (ACE2) in differentiating airway epithelia. BBA Adv. 2022;2:100044 pubmed publisher
immunohistochemistry - paraffin section; mouse; loading ...; fig 3e	Biagioli M, Marchianò S, Roselli R, Di Giorgio C, Bellini R, Bordoni M, et al. Discovery of a AHR pelargonidin agonist that counter-regulates Ace2 expression and attenuates ACE2-SARS-CoV-2 interaction. Biochem Pharmacol. 2021;188:114564 pubmed publisher
immunohistochemistry - frozen section; human; 1:200; fig 4a	Andrews M, Mukhtar T, Eze U, Simoneau C, Perez Y, Mostajo Radji M, et al. Tropism of SARS-CoV-2 for Developing Human Cortical Astrocytes. bioRxiv. 2021;: pubmed publisher
	Elste J, Cast N, Udawatte S, Adhikari K, Payen S, Verma S, et al. Co-Expression of Niemann-Pick Type C1-Like1 (NPC1L1) with ACE2 Receptor Synergistically Enhances SARS-CoV-2 Entry and Fusion. Biomedicines. 2024;12: pubmed publisher
	Bernauer H, Schl xf6 r A, Maier J, Bannert N, Hanack K, Ivanusic D. tANCHOR fast and cost-effective cell-based immunization approach with focus on the receptor-binding domain of SARS-CoV-2. Biol Methods Protoc. 2023;8:bpad030 pubmed publisher
	Zhang W, Golynker I, Brosh R, Fajardo A, Zhu Y, Wudzinska A, et al. Mouse genome rewriting and tailoring of three important disease loci. Nature. 2023;623:423-431 pubmed publisher
	Mahalingam G, Arjunan P, Periyasami Y, Dhyani A, Devaraju N, Rajendiran V, et al. Correlating the differences in the receptor binding domain of SARS-CoV-2 spike variants on their interactions with human ACE2 receptor. Sci Rep. 2023;13:8743 pubmed publisher
	Malik J, Acharya A, Avedissian S, Byrareddy S, Fletcher C, Podany A, et al. ACE-2, TMPRSS2, and Neuropilin-1 Receptor Expression on Human Brain Astrocytes and Pericytes and SARS-CoV-2 Infection Kinetics. Int J Mol Sci. 2023;24: pubmed publisher
	Ma X, Liang J, Zhu G, Bhoria P, Shoara A, MacKeigan D, et al. SARS-CoV-2 RBD and Its Variants Can Induce Platelet Activation and Clearance: Implications for Antibody Therapy and Vaccinations against COVID-19. Research (Wash D C). 2023;6:0124 pubmed publisher
	Chen Y, Song W, Li C, Wang J, Liu F, Ye Z, et al. COVID-19 mRNA vaccine protects against SARS-CoV-2 Omicron BA.1 infection in diet-induced obese mice through boosting host innate antiviral responses. EBioMedicine. 2023;89:104485 pubmed publisher
	Loo L, Waller M, Moreno C, Cole A, Stella A, Pop O, et al. Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. PLoS Biol. 2023;21:e3001967 pubmed publisher
	Onnis A, Andreano E, Cassioli C, Finetti F, Della Bella C, Staufer O, et al. SARS-CoV-2 Spike protein suppresses CTL-mediated killing by inhibiting immune synapse assembly. J Exp Med. 2023;220: pubmed publisher
	Endo Y, Hickerson B, Ilyushina N, Mohan N, Peng H, Takeda K, et al. Identification of a pharmacological approach to reduce ACE2 expression and development of an in vitro COVID-19 viral entry model. J Virus Erad. 2022;8:100307 pubmed publisher
	Ruan D, Ye Z, Yuan S, Li Z, Zhang W, Ong C, et al. Human early syncytiotrophoblasts are highly susceptible to SARS-CoV-2 infection. Cell Rep Med. 2022;3:100849 pubmed publisher
	Lu Y, Zhu Q, Fox D, Gao C, Stanley S, Luo K. SARS-CoV-2 down-regulates ACE2 through lysosomal degradation. Mol Biol Cell. 2022;33:ar147 pubmed publisher
	Semple S, Alkie T, Jenik K, Warner B, Tailor N, Kobasa D, et al. More tools for our toolkit: The application of HEL-299 cells and dsRNA-nanoparticles to study human coronaviruses in vitro. Virus Res. 2022;321:198925 pubmed publisher
	LeBlanc E, Colpitts C. The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor. Sci Rep. 2022;12:12899 pubmed publisher
	Brady M, McQuaid C, Solorzano A, JOHNSON A, Combs A, Venkatraman C, et al. Spike protein multiorgan tropism suppressed by antibodies targeting SARS-CoV-2. Commun Biol. 2021;4:1318 pubmed publisher
	Kashyap T, Murray J, Walker C, Chang H, Tamir S, Hou B, et al. Selinexor, a novel selective inhibitor of nuclear export, reduces SARS-CoV-2 infection and protects the respiratory system in vivo. Antiviral Res. 2021;192:105115 pubmed publisher
	Donofrio G, Franceschi V, Macchi F, Russo L, Rocci A, Marchica V, et al. A Simplified SARS-CoV-2 Pseudovirus Neutralization Assay. Vaccines (Basel). 2021;9: pubmed publisher
	Alfi O, Yakirevitch A, Wald O, Wandel O, Izhar U, Oiknine Djian E, et al. Human Nasal and Lung Tissues Infected Ex Vivo with SARS-CoV-2 Provide Insights into Differential Tissue-Specific and Virus-Specific Innate Immune Responses in the Upper and Lower Respiratory Tract. J Virol. 2021;95:e0013021 pubmed publisher
	Hernández J, Beaty D, Fruhwirth L, Lopes Chaves A, Riordan N. Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells. J Transl Med. 2021;19:149 pubmed publisher
	Suresh V, Parida D, Minz A, Sethi M, Sahoo B, Senapati S. Tissue Distribution of ACE2 Protein in Syrian Golden Hamster (Mesocricetus auratus) and Its Possible Implications in SARS-CoV-2 Related Studies. Front Pharmacol. 2020;11:579330 pubmed publisher
	Firpo M, Mastrodomenico V, Hawkins G, Prot M, Levillayer L, Gallagher T, et al. Targeting Polyamines Inhibits Coronavirus Infection by Reducing Cellular Attachment and Entry. ACS Infect Dis. 2021;7:1423-1432 pubmed publisher
	Surendran H, Nandakumar S, Pal R. Human Induced Pluripotent Stem Cell-Derived Lung Epithelial System for SARS-CoV-2 Infection Modeling and Its Potential in Drug Repurposing. Stem Cells Dev. 2020;29:1365-1369 pubmed publisher
	Chen M, Shen W, Rowan N, Kulaga H, Hillel A, Ramanathan M, et al. Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication. Eur Respir J. 2020;56: pubmed publisher
	Stewart C, Gay C, Ramkumar K, Cargill K, Cardnell R, Nilsson M, et al. Lung cancer models reveal SARS-CoV-2-induced EMT contributes to COVID-19 pathophysiology. bioRxiv. 2021;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

ACE2 Recombinant Rabbit Monoclonal Antibody (SN0754)

Catalog # :

MA5-32307

Quantity :

100 uL

Price :

US 470.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:1,000, Western Blot: 1:1,000-1:5,000

Species :

Human, Mouse, Rat

Clone :

SN0754

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Immunogen :

Synthetic peptide within Human ACE2 aa 181-230

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:1,000, Western Blot: 1:1,000-1:5,000

Aliases :

2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885

more info or order :

Invitrogen product webpage