NLRP3 Recombinant Rabbit Monoclonal Antibody (SC06-23) | Invitrogen MA5-32255 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

NLRP3 Recombinant Rabbit Monoclonal Antibody (SC06-23)

catalog :

MA5-32255

quantity :

100 uL

price :

US 480.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SC06-23

The same clone is also sold as:

Novus Biologicals: NBP2-67639

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 8

Reference
Li J, Wang Z, Tan H, Tang M. ALKBH5-mediated m6A demethylation of pri-miR-199a-5p exacerbates myocardial ischemia/reperfusion injury by regulating TRAF3-mediated pyroptosis. J Biochem Mol Toxicol. 2024;38:e23710 pubmed publisher
Tang B, Li Y, Xu X, Du G, Wang H. Electroacupuncture Ameliorates Neuronal Injury by NLRP3/ASC/Caspase-1 Mediated Pyroptosis in Cerebral Ischemia-Reperfusion. Mol Neurobiol. 2024;61:2357-2366 pubmed publisher
Benavides S, Palavecino R, Riquelme J, Montecinos L, Finkelstein J, Donoso P, et al. Inhibition of NOX2 or NLRP3 inflammasome prevents cardiac remote ischemic preconditioning. Front Physiol. 2023;14:1327402 pubmed publisher
Makhija S, Griffett J, Veerakanellore G, Burris T, Elgendy B, Griffett K. REV-ERB activation as a novel pharmacological approach for treating inflammatory pain. Front Pharmacol. 2023;14:1171931 pubmed publisher
Zhao Y, Sun R, Duan F, Wang F, Li Y, Qian X, et al. Intravitreal slow-release dexamethasone alleviates traumatic proliferative vitreoretinopathy by inhibiting persistent inflammation and Müller cell gliosis in rabbits. Int J Ophthalmol. 2023;16:22-32 pubmed publisher
Jahan S, Awaja N, Hess B, Hajjar S, Sad S, Lohnes D. The transcription factor Cdx2 regulates inflammasome activity through expression of the NLRP3 suppressor TRIM31 to maintain intestinal homeostasis. J Biol Chem. 2022;298:102386 pubmed publisher
Liu C, Wu J, Jia H, Lu C, Liu J, Li Y, et al. Oncostatin M promotes the ox-LDL-induced activation of NLRP3 inflammasomes via the NF-κB pathway in THP-1 macrophages and promotes the progression of atherosclerosis. Ann Transl Med. 2022;10:456 pubmed publisher
Na L, Wang S, Liu T, Zhang L. Ultrashort Wave Combined with Human Umbilical Cord Mesenchymal Stem Cell (HUC-MSC) Transplantation Inhibits NLRP3 Inflammasome and Improves Spinal Cord Injury via MK2/TTP Signalling Pathway. Biomed Res Int. 2020;2020:3021750 pubmed publisher

product information

Product Type :

Antibody

Product Name :

NLRP3 Recombinant Rabbit Monoclonal Antibody (SC06-23)

Catalog # :

MA5-32255

Quantity :

100 uL

Price :

US 480.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat

Applications :

Flow Cytometry: 1:500-1:1,000, Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:100-1:400, Western Blot: 1:500-1:1,000

Species :

Human, Mouse, Rat

Clone :

SC06-23

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site domain, and a leucine-rich repeat motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome, and neonatal-onset multisystem inflammatory disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Immunogen :

Recombinant protein within Human NLRP3 aa 5-161

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:500-1:1,000, Immunocytochemistry: 1:100-1:500, Immunohistochemistry (Paraffin): 1:100-1:400, Western Blot: 1:500-1:1,000

Aliases :

AGTAVPRL; AII; AII/AVP; Angiotensin/vasopressin receptor AII/AVP-like; AVP; C1orf7; caterpiller protein 1.1; Cias1; CLR1.1; cold autoinflammatory syndrome 1 homolog; cold autoinflammatory syndrome 1 protein; cold autoinflammatory syndrome 1 protein homolog; Cold-induced autoinflammatory syndrome 1 protein; cryopyrin; FCAS; FCAS1; FCU; FLJ95925; mast cell maturation inducible protein 1; mast cell maturation-associated-inducible protein 1; Mmig1; MWS; NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NACHT/LRR/pyrin domain-containing protein 3; NALP3; NLR family pyrin domain containing 3; NLR family, pyrin domain containing 3; Nlrp3; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3; PYPAF1; PYRIN-containing APAF1-like protein 1