Adiponectin Receptor 1 Recombinant Rabbit Monoclonal Antibody (SC69-04)

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Adiponectin Receptor 1 Recombinant Rabbit Monoclonal Antibody (SC69-04)

catalog :

MA5-32249

quantity :

100 uL

price :

US 464.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SC69-04

The same clone is also sold as:

Novus Biologicals: NBP2-67631

reactivity :

human, mouse, rat, zebrafish

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Reference
Alldred M, Lee S, Ginsberg S. Adiponectin Modulation by Genotype and Maternal Choline Supplementation in a Mouse Model of Down Syndrome and Alzheimer's Disease. J Clin Med. 2021;10: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Adiponectin Receptor 1 Recombinant Rabbit Monoclonal Antibody (SC69-04)

Catalog # :

MA5-32249

Quantity :

100 uL

Price :

US 464.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse, Rat, Zebrafish

Applications :

Flow Cytometry: 1:50-1:100, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:5,000

Species :

Human, Mouse, Rat, Zebrafish

Clone :

SC69-04

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Adiponectin (also known as 30- kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR-. Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.

Immunogen :

Synthetic peptide within Human ADIPOR1 aa 5-54

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50-1:100, Immunocytochemistry: 1:50-1:200, Immunohistochemistry (Paraffin): 1:50-1:200, Western Blot: 1:1,000-1:5,000

Aliases :

2810031L11Rik; ACDCR1; adiponectin receptor 1; adiponectin receptor protein 1; Adipor1; CGI45; CGI-45; PAQR1; Parq1; Progestin and adipoQ receptor family member 1; Progestin and adipoQ receptor family member I; TESBP1A