TSPO Recombinant Rabbit Monoclonal Antibody (SA90-03) | Invitrogen MA5-31966 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TSPO Recombinant Rabbit Monoclonal Antibody (SA90-03)

catalog :

MA5-31966

quantity :

100 uL

price :

US 464.00

clonality :

recombinant

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

SA90-03

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

TSPO Recombinant Rabbit Monoclonal Antibody (SA90-03)

Catalog # :

MA5-31966

Quantity :

100 uL

Price :

US 464.00

Clonality :

Recombinant Monoclonal

Purity :

protein A

Host :

Rabbit

Reactivity :

Human, Mouse

Applications :

Flow Cytometry: 1:1000, Immunocytochemistry: 1:1000, Immunohistochemistry (Paraffin): 1:400-1:1000, Western Blot: 1:2,000

Species :

Human, Mouse

Clone :

SA90-03

Isotype :

IgG

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Mitochondrial peripheral-type benzodiazepine receptor (PBR) is an indispensable element of the steroidogenic machinery, where it mediates the delivery of cholesterol to the inner mitochondrial side chain cleavage cytochrome P-450 upon ligand activation. PBR is composed of three subunits, an isoquinoline binding site, a voltage-dependent anion channel and an adenine nucleotide carrier. PBR is genetically conserved from bacteria to humans and in humans is widely expressed in peripheral organs, whereas in the brain, it is sparse and located mainly in glial cells. Peroxisome proliferator perfluordecanoic acid (PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR.

Immunogen :

Synthetic peptide within Human PBR aa 120-169

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:1000, Immunocytochemistry: 1:1000, Immunohistochemistry (Paraffin): 1:400-1:1000, Western Blot: 1:2,000

Aliases :

Benzodiazepin receptor (peripheral); benzodiazepine peripheral binding site; benzodiazepine receptor, peripheral; BPBS; BZRP; DBI; IBP; isoquinoline-binding protein; MBR; mDRC; mitochondrial benzodiazepine receptor; OTTHUMP00000028891; PBR; PBS; peripheral-type benzodiazepine receptor; pk18; PKBS; PTBR; Ptbzr; PTBZR02; RATPTBZR02; translocator protein; translocator protein (18kDa); TSPO; Tspo1