ACE2 Monoclonal Antibody (CL4035) | Invitrogen MA5-31395 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ACE2 Monoclonal Antibody (CL4035)

catalog :

MA5-31395

quantity :

100 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CL4035

The same clone is also sold as:

Novus Biologicals: NBP2-59037

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 10

Reference
Azevedo M, Macedo S, Canberk S, Cardoso L, Gaspar T, Pestana A, et al. Significance of Furin Expression in Thyroid Neoplastic Transformation. Cancers (Basel). 2023;15: pubmed publisher
Sadhu S, Dalal R, Dandotiya J, Binayke A, Singh V, Tripathy M, et al. IL-9 aggravates SARS-CoV-2 infection and exacerbates associated airway inflammation. Nat Commun. 2023;14:4060 pubmed publisher
Macedo S, Pestana A, Santos L, Neves C, Guimar xe3 es S, Duarte Neto A, et al. Detection of SARS-CoV-2 infection in thyroid follicular cells from a COVID-19 autopsy series. Eur Thyroid J. 2022;11: pubmed publisher
Bezerra B, Silva G, Coelho S, Correa I, Souza M, Macedo K, et al. Hydroxypropyl-beta-cyclodextrin (HP-BCD) inhibits SARS-CoV-2 replication and virus-induced inflammatory cytokines. Antiviral Res. 2022;205:105373 pubmed publisher
Biagioli M, Marchian xf2 S, Roselli R, Di Giorgio C, Bellini R, Bordoni M, et al. GLP-1 Mediates Regulation of Colonic ACE2 Expression by the Bile Acid Receptor GPBAR1 in Inflammation. Cells. 2022;11: pubmed publisher
Magalh xe3 es A, Ricardo S, Moreira A, Nunes M, Tavares M, Pinto R, et al. InfectionCMA: A Cell MicroArray Approach for Efficient Biomarker Screening in In Vitro Infection Assays. Pathogens. 2022;11: pubmed publisher
Mitamura Y, Schulz D, Oro S, Li N, Kolm I, Lang C, et al. Cutaneous and systemic hyperinflammation drives maculopapular drug exanthema in severely ill COVID-19 patients. Allergy. 2022;77:595-608 pubmed publisher
Pozzi G, Masselli E, Gobbi G, Mirandola P, Taborda Barata L, Ampollini L, et al. Hydrogen Sulfide Inhibits TMPRSS2 in Human Airway Epithelial Cells: Implications for SARS-CoV-2 Infection. Biomedicines. 2021;9: pubmed publisher
Liu J, Bodnar B, Meng F, Khan A, Wang X, Saribas S, et al. Epigallocatechin gallate from green tea effectively blocks infection of SARS-CoV-2 and new variants by inhibiting spike binding to ACE2 receptor. Cell Biosci. 2021;11:168 pubmed publisher
Hernández J, Beaty D, Fruhwirth L, Lopes Chaves A, Riordan N. Dodging COVID-19 infection: low expression and localization of ACE2 and TMPRSS2 in multiple donor-derived lines of human umbilical cord-derived mesenchymal stem cells. J Transl Med. 2021;19:149 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ACE2 Monoclonal Antibody (CL4035)

Catalog # :

MA5-31395

Quantity :

100 uL

Price :

US 480.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:20,000-1:50,000, Western Blot: 1 ug/mL

Species :

Human

Clone :

CL4035

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Immunogen :

Recombinant protein corresponding to Human ACE2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:20,000-1:50,000, Western Blot: 1 ug/mL

Aliases :

2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885