ACE2 Monoclonal Antibody (CL4013) | Invitrogen MA5-31394 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

ACE2 Monoclonal Antibody (CL4013)

catalog :

MA5-31394

quantity :

100 uL

price :

US 480.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CL4013

The same clone is also sold as:

Novus Biologicals: NBP2-59036

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 3

Reference
Zinserling V, Semenova N, Bikmurzina A, Kruglova N, Rybalchenko O, Markov A. SARS-CoV-2-Induced Pathology-Relevance to COVID-19 Pathophysiology. Pathophysiology. 2022;29:281-297 pubmed publisher
Fernando S, Chen X, Cheng K, Wong B, Qi S, Jiang L, et al. ACE inhibitors on ACE1, ACE2, and TMPRSS2 expression and spheroid attachment on human endometrial Ishikawa cells. Reprod Biol. 2022;22:100666 pubmed publisher
Steenblock C, Richter S, Berger I, Barovic M, Schmid J, Schubert U, et al. Viral infiltration of pancreatic islets in patients with COVID-19. Nat Commun. 2021;12:3534 pubmed publisher

product information

Product Type :

Antibody

Product Name :

ACE2 Monoclonal Antibody (CL4013)

Catalog # :

MA5-31394

Quantity :

100 uL

Price :

US 480.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:10,000-1:20,000, Western Blot: 1 ug/mL

Species :

Human

Clone :

CL4013

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Immunogen :

Recombinant protein corresponding to Human ACE2

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:10,000-1:20,000, Western Blot: 1 ug/mL

Aliases :

2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885