Cyclophilin B Monoclonal Antibody (CL3901) | Invitrogen MA5-31392 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Cyclophilin B Monoclonal Antibody (CL3901)

catalog :

MA5-31392

quantity :

100 uL

price :

US 473.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CL3901

The same clone is also sold as:

Novus Biologicals: NBP2-59781
Abcam: ab236760

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Hromas R, Srinivasan G, Yang M, Jaiswal A, Totterdale T, Phillips L, et al. BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1. iScience. 2022;25:105626 pubmed publisher

product information

Product Type :

Antibody

Product Name :

Cyclophilin B Monoclonal Antibody (CL3901)

Catalog # :

MA5-31392

Quantity :

100 uL

Price :

US 473.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunohistochemistry (Paraffin): 1:5,000-1:10,000, Western Blot: 1 ug/mL

Species :

Human, Mouse, Rat

Clone :

CL3901

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Immunophilins are a family of soluble cytosolic receptors capable of binding to one of two major immunosuppressant agents - cyclosporin A (CsA) or FK506. Proteins which bind FK506 are termed FK506 Binding Proteins (FKBP's) and those which bind cyclosporin A are called cyclophilins (CyP). Both CyP:CsA and FKBP:FK506 complexes have been shown to inhibit calcineurin, a calcium and calmodulin dependent protein phosphatase which has been implicated as an important signaling enzyme in T-cell activation. Thus, providing a possible mechanism of immunosuppression by CsA and FK506. Immunophilins function as peptidyl prolyl cis-trans-isomerases (PPIase) whose activity is inhibited by their respective immunosuppressant compounds. As PPIase's, immunophilins accelerate folding of some proteins both in vivo and in vitro by catalyzing slow steps in the initial folding and rearrangement of proline containing proteins.

Immunogen :

Synthetic peptide corresponding to Human PPIB

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:5,000-1:10,000, Western Blot: 1 ug/mL

Aliases :

AA408962; AA553318; AI844835; Cphn2; Cphn-2; cyclophilin B; cyclophilin-like protein; Cyp B; CyP-20b; CYPB; CYP-S1; EC 5.2.1.8; epididymis secretory protein Li 39; HEL-S-39; OI9; Peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase; PPIase B; Ppib; Rotamase; Rotamase B; S-cyclophilin; S-cyclophylin; SCYLP