Dicer Monoclonal Antibody (CL0378) | Invitrogen MA5-31353 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Dicer Monoclonal Antibody (CL0378)

catalog :

MA5-31353

quantity :

100 uL

price :

US 524.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CL0378

The same clone is also sold as:

Novus Biologicals: NBP2-30699

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 2

Reference
Paloviita P, Hyd xe9 n Granskog C, Yohannes D, Paluoja P, Kere J, Tapanainen J, et al. Small RNA expression and miRNA modification dynamics in human oocytes and early embryos. Genome Res. 2021;31:1474-1485 pubmed publisher
Wilczynski M, Kielbik M, Senderowska D, Krawczyk T, Szymanska B, Klink M, et al. MiRNA-103/107 in Primary High-Grade Serous Ovarian Cancer and Its Clinical Significance. Cancers (Basel). 2020;12: pubmed publisher

product information

Product Type :

Antibody

Product Name :

Dicer Monoclonal Antibody (CL0378)

Catalog # :

MA5-31353

Quantity :

100 uL

Price :

US 524.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Immunocytochemistry: 2-10 ug/mL, Immunohistochemistry (Paraffin): 1:200-1:500, Western Blot: 1 ug/mL

Species :

Human

Clone :

CL0378

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

Dicer is a double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. It cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a means to specifically regulate the expression of target genes.

Immunogen :

Recombinant protein corresponding to Human DICER1

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 2-10 ug/mL, Immunohistochemistry (Paraffin): 1:200-1:500, Western Blot: 1 ug/mL

Aliases :

1110006F08Rik; D12Ertd7e; DCR; DCR1; DCR-1; Dicer; dicer 1 ribonuclease III; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease III; dicer 1, ribonuclease type III; Dicer1; Dicer1, Dcr-1 homolog; Dicer1e; double-strand-specific ribonuclease mDCR-1; endoribonuclease Dicer; Helicase MOI; helicase with RNAse motif; helicase-moi; HERNA; K12H4.8-LIKE; KIAA0928; mKIAA0928; MNG1; RMSE2