This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
Nicastrin Recombinant Rabbit Monoclonal Antibody (019)
catalog :
MA5-29438
quantity :
100 uL
price :
US 414.00
clonality :
recombinant
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
19
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation
product information
Product Type :
Antibody
Product Name :
Nicastrin Recombinant Rabbit Monoclonal Antibody (019)
Catalog # :
MA5-29438
Quantity :
100 uL
Price :
US 414.00
Clonality :
Recombinant Monoclonal
Purity :
protein A
Host :
Rabbit
Reactivity :
Human
Applications :
Immunocytochemistry: 1:100, Immunoprecipitation: 0.2-1 uL/mg of lysate, Western Blot: 1:500-1:1,000
Species :
Human
Clone :
19
Isotype :
IgG
Storage :
Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.
Description :
NCSTN (Nicastrin) is a gene that encodes a type I transmembrane glycoprotein that is an integral component of the multimeric gamma-secretase complex. The encoded protein cleaves integral membrane proteins, including Notch receptors and beta-amyloid precursor protein, and may be a stabilizing cofactor required for gamma-secretase complex assembly. The cleavage of beta-amyloid precursor protein yields amyloid beta peptide, the main component of the neuritic plaque and the hallmark lesion in the brains of patients with Alzheimer's disease; however, the nature of the encoded protein's role in Alzheimer's disease is not known for certain. Mutations in this gene are associated with familial acne inversa. A pseudogene of this gene is present on chromosome 21.
Immunogen :
Recombinant Human Nicastrin/NCSTN protein (Met1-Glu669)
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:100, Immunoprecipitation: 0.2-1 uL/mg of lysate, Western Blot: 1:500-1:1,000
Aliases :
9430068N19Rik; AA727311; anterior pharynx-defective 2; Aph2; ATAG1874; D1Dau13e; Kiaa0253; mKIAA0253; NCSTN; Nct; Nicastrin; OTTHUMP00000031840; UNQ1874/PRO4317
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA