beta-2 Microglobulin Monoclonal Antibody (F21-21), Biotin | Invitrogen MA5-28736 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

beta-2 Microglobulin Monoclonal Antibody (F21-21), Biotin

catalog :

MA5-28736

quantity :

1 mL

price :

US 474.00

clonality :

monoclonal

host :

mouse

conjugate :

biotin

clone name :

F21-21

reactivity :

chicken

application :

flow cytometry

product information

Product Type :

Antibody

Product Name :

beta-2 Microglobulin Monoclonal Antibody (F21-21), Biotin

Catalog # :

MA5-28736

Quantity :

1 mL

Price :

US 474.00

Clonality :

Monoclonal

Purity :

purified

Host :

Mouse

Reactivity :

Avian, Chicken

Applications :

Flow Cytometry: 1 ug/10^6 cells

Species :

Avian, Chicken

Clone :

F21-21

Isotype :

IgG1, kappa

Storage :

4 C

Description :

Beta-2-microglobulin (B2M) is a 12-14 kDa protein that is a subunit of the major histocompatibility complex (MHC) class I. Human beta 2 Microglobulin associated with HLA Class I antigens are expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells, but is absent on erythrocytes. Beta-2 microglobulin is also found in free form in the plasma. The amino acid sequence of Beta-2-microglobulin is homologous to the constant regions of immunoglobulin heavy and light chains, with a predominantly beta pleated sheet structure. The protein is ubiquitously expressed in the cytoplasm, and is involved in antigen processing and presentation. Beta-2-microglobulin also plays a role in TCR signaling, and downstream signaling in naive CD8+ cells. Beta 2-microglobulin is encoded by the B2M gene located on chromosome 15. A mutation in the Beta-2-microglobulin gene has been shown to result in hypercatabolic hypoproteinemia. Levels of beta 2 microglobulin can be used to assess renal function in kidney transplant recipients. Beta-2-microglobulin that protein can be used as a prognostic marker for HIV infection.

Immunogen :

Affinity purified chicken MHC-I molecules

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1 ug/10^6 cells

Aliases :

B2m; B2-microglobulin; b2m-W01; b2m-W03; b2m-Z01; b2m-Z02; b2m-Z03; Beta 2 microglobin; Beta 2 microglobulin; beta 2-microglobulin; beta chain of MHC class I molecules; Beta2 microglobulin; beta-2 microglobulin; beta-2 microglobulin preprotein; beta2m; beta2-m; beta-2-microglobin; beta-2-microglobulin; beta-2-microglobulin C-terminal fragment (55 AA); Beta-2-microglobulin form pI 5.3; B-F; CDABP0092; HDCMA22P; IMD43; Lactollin; Ly-m11; MHC Class I; microglobulin beta-2; Orla-B2m