DLL4 (delta-like 4) Monoclonal Antibody (MHD4-46) | Invitrogen MA5-28625 product information

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

DLL4 (delta-like 4) Monoclonal Antibody (MHD4-46)

catalog :

MA5-28625

quantity :

100 µg

price :

US 125.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

MHD4-46

reactivity :

human, mouse

application :

flow cytometry

more info or order :

Invitrogen product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
flow cytometry; mouse; 1:1000; loading ...; fig s2	Steinbuck M, Arakcheeva K, Winandy S. Novel TCR-Mediated Mechanisms of Notch Activation and Signaling. J Immunol. 2018;200:997-1007 pubmed publisher

product information

Product Type :

Antibody

Product Name :

DLL4 (delta-like 4) Monoclonal Antibody (MHD4-46)

Catalog # :

MA5-28625

Quantity :

100 µg

Price :

US 125.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

Flow Cytometry: 1-4 µg/mL, Functional Assay: Assay-Dependent

Species :

Human

Clone :

MHD4-46

Isotype :

IgG1, kappa

Storage :

4° C, do not freeze

Description :

Delta-like ligand 4 (DLL4), also know as Delta-4, is a homologue of the Drosophila delta protein, and functions as a transmembrane bound ligand to the notch receptor Notch1. DLL4 is expressed in the vasculature and plays a critical role in vascular development. It is induced by vascular endothelial growth factor (VEGF), as a negative feedback regulator to regulate angiogenic sprouting and promote the formulation of a differentiated vascular network. DLL4 has been found to be strongly expressed in tumor vessels of clear-cell renal tumors and bladder cancer, and inhibition of DLL4 results in increased vascular proliferation but defective maturation. This in turn leads to a decrease in tumor growth, with no apparent toxicity.

Immunogen :

recombinant soluble human DLL4

Format :

liquid

Applications w/Dilutions :

Flow Cytometry: 1-4 µg/mL, Functional Assay: Assay-Dependent

Aliases :

AOS6; delta 4; delta ligand 4; delta like canonical Notch ligand 4; Delta4; delta-like 4 (Drosophila); delta-like 4 homolog; delta-like 4 protein; delta-like protein 4; DLL4; Drosophila Delta homolog 4; hdelta2; MGC126344; notch ligand delta-2; notch ligand DLL4; UNQ1895/PRO4341

more info or order :

Invitrogen product webpage