CD279 (PD-1) Monoclonal Antibody (EH12.2H7) | Invitrogen MA5-28584 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD279 (PD-1) Monoclonal Antibody (EH12.2H7)

catalog :

MA5-28584

quantity :

100 ug

price :

US 174.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

EH12.2H7

The same clone is also sold as:

Wuhan Fine Biotech Co.,Ltd.: FITC-30036, PE-30036, APC-30036
Abcam: ab223562
BioLegend: 329935, 329949, 329976, 329929, 329922, 329947, 329937, 329972, 329908, 329945, 329920, 329975, 329928, 329923, 329924, 329960, 329977, 329905, 329940, 329943, 329934, 329978, 329926, 329973, 329903, 329907, 329902, 329955, 329917, 329936, 329921, 329961, 329944, 329913, 329918, 329967, 329906, 329958, 329910, 329965, 329925, 329959, 329939, 329916, 329941, 329904, 329952, 329933, 329927, 329930, 329915, 329974, 329969, 329971, 329919, 329968, 329963, 329914, 329957, 329938, 329951, 329946, 329932, 329948, 329954, 329966, 329953, 329950, 329931
Bio-Rad: MCA6133F, MCA6133PE

reactivity :

common marmoset, crab eating macaque, Bolivian squirrel monkey , human, chimpanzee, rhesus macaque

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 9

Reference
Srivastava S, Furlan S, Jaeger Ruckstuhl C, Sarvothama M, Berger C, Smythe K, et al. Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade. Cancer Cell. 2021;39:193-208.e10 pubmed publisher
Lee K, Jang S, Tian H, Kim S. NonO Is a Novel Co-factor of PRDM1 and Regulates Inflammatory Response in Monocyte Derived-Dendritic Cells. Front Immunol. 2020;11:1436 pubmed publisher
Srivastava S, Salter A, Liggitt D, Yechan Gunja S, Sarvothama M, Cooper K, et al. Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting. Cancer Cell. 2019;35:489-503.e8 pubmed publisher
Muller Durovic B, Grählert J, Devine O, Akbar A, Hess C. CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age. Aging (Albany NY). 2019;11:724-740 pubmed publisher
Petrelli A, Mijnheer G, Hoytema van Konijnenburg D, van der Wal M, Giovannone B, Mocholí E, et al. PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation. J Clin Invest. 2018;128:4669-4681 pubmed publisher
Egle A, Steurer M, Melchardt T, Weiss L, Gassner F, Zaborsky N, et al. Fludarabine and rituximab with escalating doses of lenalidomide followed by lenalidomide/rituximab maintenance in previously untreated chronic lymphocytic leukaemia (CLL): the REVLIRIT CLL-5 AGMT phase I/II study. Ann Hematol. 2018;97:1825-1839 pubmed publisher
Rivino L, Le Bert N, Gill U, Kunasegaran K, Cheng Y, Tan D, et al. Hepatitis B virus-specific T cells associate with viral control upon nucleos(t)ide-analogue therapy discontinuation. J Clin Invest. 2018;128:668-681 pubmed publisher
Hong J, Silveira E, Amancha P, Byrareddy S, Gumber S, Chang K, et al. Early initiation of antiretroviral treatment postSIV infection does not resolve lymphoid tissue activation. AIDS. 2017;31:1819-1824 pubmed publisher
Gwiazda K, Grier A, Sahni J, Burleigh S, Martin U, Yang J, et al. High Efficiency CRISPR/Cas9-mediated Gene Editing in Primary Human T-cells Using Mutant Adenoviral E4orf6/E1b55k "Helper" Proteins. Mol Ther. 2016;24:1570-80 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD279 (PD-1) Monoclonal Antibody (EH12.2H7)

Catalog # :

MA5-28584

Quantity :

100 ug

Price :

US 174.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey

Applications :

Flow Cytometry: 1-4 ug/mL, Immunohistochemistry (Frozen): Assay-Dependent

Species :

Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Rhesus Monkey

Clone :

EH12.2H7

Isotype :

IgG1, kappa

Storage :

4 C, do not freeze

Description :

Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of 'danger signals' such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

Immunogen :

Recombinant human CD279

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1-4 ug/mL, Immunohistochemistry (Frozen): Assay-Dependent

Aliases :

CD279; EGK_05005; hPD1; hPD-1; hPD-l; hSLE1; Ly101; mPD-1; PD1; PD-1; Pdc1; Pdcd1; programmed cell death 1; programmed cell death 1 protein; programmed cell death protein 1; programmed cell death protein 1-like; programmed death 1; Protein PD1; protein PD-1; sCD279; SLEB2; soluble CD279; systemic lupus erythematosus susceptibility 2