Complement C5b-9 Monoclonal Antibody (3R2/0) | Invitrogen MA5-28502 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

Complement C5b-9 Monoclonal Antibody (3R2/0)

catalog :

MA5-28502

quantity :

100 ug

price :

US 792.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3R2/0

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

product information

Product Type :

Antibody

Product Name :

Complement C5b-9 Monoclonal Antibody (3R2/0)

Catalog # :

MA5-28502

Quantity :

100 ug

Price :

US 792.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Human

Applications :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Species :

Human

Clone :

3R2/0

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

The complement system is a fundamental part of innate immunity, consisting of over 45 genes that encode various complement components, regulators, and receptors. The complement C5b-9 complex, also known as the Membrane Attack Complex (MAC), plays a crucial role in the immune defense mechanism. It includes the sequential assembly of proteins C5b, C6, C7, C8, and multiple copies of C9. This complex forms transmembrane channels that puncture the cell membrane of target cells, leading to cell lysis. Specifically, MAC has significant implications in mediating cell death in both pathogenic organisms and cancer cells. The genes involved are clustered across the human genome, mainly organized in three significant loci. The understanding of the C5b-9 complex's function extends beyond its antimicrobial roles to include its interactions with tumor cells, where it can induce cell death and influence cancer progression.

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent, Western Blot: Assay-dependent

Aliases :

C5b-9; MAC Complex; Membrane Attack Complex