CD115 (c-fms) Monoclonal Antibody (ROS-AV170) | Invitrogen MA5-28454 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD115 (c-fms) Monoclonal Antibody (ROS-AV170)

catalog :

MA5-28454

quantity :

100 ug

price :

US 357.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

ROS-AV170

reactivity :

chicken

application :

immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 1

Reference
Hu T, Wu Z, Bush S, Freem L, Vervelde L, Summers K, et al. Characterization of Subpopulations of Chicken Mononuclear Phagocytes That Express TIM4 and CSF1R. J Immunol. 2019;202:1186-1199 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD115 (c-fms) Monoclonal Antibody (ROS-AV170)

Catalog # :

MA5-28454

Quantity :

100 ug

Price :

US 357.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Mouse

Reactivity :

Chicken

Applications :

Flow Cytometry: 1:50-1:200, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent

Species :

Chicken

Clone :

ROS-AV170

Isotype :

IgG1

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CSF1R (FMS) is involved in the production, differentiation, and function of macrophages, and is implicated in promyelocytic leukemias. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. CSF1R is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in the gene encoding CSF1R have been associated with a predisposition to myeloid malignancy.Tyrosine-protein kinase that acts as cell-surface receptor for CSF1 and IL34 and plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, such as macrophages and monocytes. Promotes the release of proinflammatory chemokines in response to IL34 and CSF1, and plays an important role in innate immunity and in inflammatory processes. The first intron of the CSF1R gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. Mutations in the CSF1R gene have been associated with a predisposition to myeloid malignancy.

Immunogen :

Purified ChCSF1R-Fc fusion protein

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: 1:50-1:200, Immunocytochemistry: Assay-dependent, Immunohistochemistry (Frozen): Assay-dependent

Aliases :

AI323359; CD115; CD115 antigen; C-FMS; colony stimulating factor 1 receptor; colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog; CSF-1 receptor; CSF1R; CSF-1R; CSF-1-R; CSFIR; Csfmr; CSFR; EC 2.7.10.1; FIM2; Fim-2; FMS; fms proto-oncogene; HDLS; kinase CSFR; macrophage colony stimulating factor I receptor; macrophage colony-stimulating factor 1 receptor; McDonough feline sarcoma viral (v-fms) oncogene homolog; M-CSFR; M-CSF-R; mrfms; OTTHUMP00000224093; protein-tyrosine kinase; proto-oncogene c-Fms; proto-oncogene fms