CD172a (SIRP alpha) Monoclonal Antibody (DH59B) | Invitrogen MA5-28298 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD172a (SIRP alpha) Monoclonal Antibody (DH59B)

catalog :

MA5-28298

quantity :

100 ug

price :

US 357.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

DH59B

The same clone is also sold as:

Bio-Rad: MCA6079

reactivity :

dogs, bovine

application :

immunohistochemistry, flow cytometry, immunohistochemistry - frozen section

citations: 3

Reference
Witonsky S, Buechner Maxwell V, Santonastasto A, Pleasant R, Werre S, Wagner B, et al. Can levamisole upregulate the equine cell-mediated macrophage (M1) dendritic cell (DC1) T-helper 1 (CD4 Th1) T-cytotoxic (CD8) immune response in vitro?. J Vet Intern Med. 2019;33:889-896 pubmed publisher
Takada M, Parys M, Gregory Bryson E, Vilar Saavedra P, Kiupel M, Yuzbasiyan Gurkan V. A novel canine histiocytic sarcoma cell line: initial characterization and utilization for drug screening studies. BMC Cancer. 2018;18:237 pubmed publisher
Neeland M, Shi W, Collignon C, Meeusen E, Didierlaurent A, de Veer M. The Adjuvant System AS01 upregulates neutrophil CD14 expression and neutrophil-associated antigen transport in the local lymphatic network. Clin Exp Immunol. 2017;: pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD172a (SIRP alpha) Monoclonal Antibody (DH59B)

Catalog # :

MA5-28298

Quantity :

100 ug

Price :

US 357.00

Clonality :

Monoclonal

Host :

Mouse

Reactivity :

Bovine, Canine

Applications :

Flow Cytometry: Neat-1:10, Immunohistochemistry (Frozen): Assay-dependent

Species :

Bovine, Canine

Clone :

DH59B

Isotype :

IgG1

Storage :

4 C, do not freeze

Description :

SIRP alpha (CD172a, signal-regulatory protein alpha) is a receptor-type transmembrane glycoprotein expressed on cells of myeloid origin, including granulocytes, dendritic cells (DCs), macrophages, mast cells and hematopoietic stem cells. SIRP alpha acts as a substrate for several activated tyrosine kinases, including EGFR, PDGFR, src and insulin receptor and is involved in the negative regulation of receptor tyrosine kinase-coupled signaling pathways. The ligand binding of SIRP alpha to integrin-associated protein CD47 results in tyrosine kinase phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIMs) within the cytoplasmic region of SIRP alpha, which mediates the recruitment and activation of the tyrosine phosphatases SHP-1 and SHP-2. Ligation of SIRP alpha with CD47 has been demonstrated in several regulatory processes, including the inhibition of host cell phagocytosis by macrophages and the bi-directional activation of T cells and DCs. SIRP alpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion, and plays a general role in different physiological and pathological processes. Cancer cells highly express CD47, which activates SIRP alpha and inhibits macrophage-mediated destruction of cancerous cell growth.

Immunogen :

Cells from multiple species with the final screening of the fusion on cells from dog

Format :

Liquid

Applications w/Dilutions :

Flow Cytometry: Neat-1:10, Immunohistochemistry (Frozen): Assay-dependent

Aliases :

AI835480; Bit; brain Ig-like molecule with tyrosine-based activation motifs; Brain immunoglobulin like protein with tyrosine - based activation motifs; brain immunological-like with tyrosine-based motifs; brain-immunoglobulin-like molecule with tyrosine-based activation motifs; CD172; CD172 alpha; CD172 antigen-like family member A; CD172A; Inhibitory receptor SHPS-1; macrophage fusion receptor; Macrophage membrane protein MFP150; MFR; mSIRP-alpha1; Myd1; MYD-1; myD-1 antigen; p84; Protein tyrosine phosphatase non-receptor type substrate 1 (SHP substrate 1); protein tyrosine phosphatase, non-receptor type substrate 1; Protein tyrosine phosphatase, non-receptor type substrate 1 (SHP substrate 1); Ptpns1; SHP substrate 1; SHP-1; SHPS1; SHPS-1; signal regulatory protein alpha; signal-regulatory protein alpha; signal-regulatory protein alpha-1; Signal-regulatory protein alpha-2; Signal-regulatory protein alpha-3; SIRP; Sirpa; SIRPalpha; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3; swc3; swine workshop cluster 3 antigen; swine workshop cluster 3 antigen precursor; tyrosine phosphatase SHP substrate 1; tyrosine-protein phosphatase non-receptor type substrate 1