CD365 (TIM1) Monoclonal Antibody (RMT1-10) | Invitrogen MA5-28211 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

CD365 (TIM1) Monoclonal Antibody (RMT1-10)

catalog :

MA5-28211

quantity :

100 ug

price :

US 332.00

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

RMT1-10

The same clone is also sold as:

Bio-Rad: MCA5788F, MCA5788GA, MCA5788PE
Bio X Cell: BE0113-1MG, BE0113-50MG, BE0113-100MG, BE0113-5MG, BE0113-25MG

reactivity :

mouse

application :

immunocytochemistry, flow cytometry

citations: 6

Reference
Zhang X, Liu C, Li Z, Ding L, Zhou Y, Zhang D, et al. Sacubitril/valsartan ameliorates tubulointerstitial fibrosis by restoring mitochondrial homeostasis in diabetic kidney disease. Diabetol Metab Syndr. 2024;16:40 pubmed publisher
Li Z, Ding L, Ma R, Zhang Y, Zhang Y, Ni W, et al. Activation of HIF-1α C-terminal transactivation domain protects against hypoxia-induced kidney injury through hexokinase 2-mediated mitophagy. Cell Death Dis. 2023;14:339 pubmed publisher
Zhang Z, Chen H, Zhou L, Li C, Lu G, Wang L. Macrophage‑derived exosomal miRNA‑155 promotes tubular injury in ischemia‑induced acute kidney injury. Int J Mol Med. 2022;50: pubmed publisher
Cao J, Wang B, Tang T, Wen Y, Li Z, Feng S, et al. Exosomal miR-125b-5p deriving from mesenchymal stem cells promotes tubular repair by suppression of p53 in ischemic acute kidney injury. Theranostics. 2021;11:5248-5266 pubmed publisher
Tang T, Wang B, Wu M, Li Z, Feng Y, Cao J, et al. Extracellular vesicle-encapsulated IL-10 as novel nanotherapeutics against ischemic AKI. Sci Adv. 2020;6:eaaz0748 pubmed publisher
Cao J, Wang B, Tang T, Lv L, Ding Z, Li Z, et al. Three-dimensional culture of MSCs produces exosomes with improved yield and enhanced therapeutic efficacy for cisplatin-induced acute kidney injury. Stem Cell Res Ther. 2020;11:206 pubmed publisher

product information

Product Type :

Antibody

Product Name :

CD365 (TIM1) Monoclonal Antibody (RMT1-10)

Catalog # :

MA5-28211

Quantity :

100 ug

Price :

US 332.00

Clonality :

Monoclonal

Purity :

protein A

Host :

Rat

Reactivity :

Mouse

Applications :

ELISA: Assay-dependent, Flow Cytometry: 1:25-1:200, Immunocytochemistry: Assay-dependent

Species :

Mouse

Clone :

RMT1-10

Isotype :

IgG2a

Storage :

Store at 4 C short term. For long term storage, store at -20 C, avoiding freeze/thaw cycles.

Description :

CD365 also known as T-cell immunoglobulin and mucin domain 1 (Tim-1) is a type 1 surface glycoprotein that consists of extracellular N-terminal immunoglobulin V-like domain and a mucin domain, and a short cytoplasmic tail. The endogenous ligand for CD365 is Tim-4. In addition, CD365 is known to be a cellular receptor or co-receptor for a number of viruses including hepatitis A and C viruses, Ebola virus, Marburg virus, Dengue virus, Zika virus, West Nile virus, and Japanese encephalitis virus. The direct binding of the viruses by CD365 occurs via phosphatildyl-serine exposed on viral envelopes. Polymorphisms within human CD365 gene (HAVCR1) are associated with susceptibility to infection and the disease severity. CD365 has also been implicated in the T cell co-stimulation. CD365 is primarily expressed in epithelial cells. It is also highly expressed in A549, 769-P and Caco-2 and cell lines. CD365 exists also as a soluble protein generated by metalloproteinase mediated proteolytic cleavage of the surface protein.

Immunogen :

Full-length mouse Tim-1-Ig, containing both the IgV and mucin domains of Tim-1

Format :

Liquid

Applications w/Dilutions :

ELISA: Assay-dependent, Flow Cytometry: 1:25-1:200, Immunocytochemistry: Assay-dependent

Aliases :

AI503787; CD365; HAVCR; HAVCR1; HAVcr-1; Hepatitis A virus cellular receptor 1; hepatitis A virus cellular receptor 1 homolog; Kidney injury molecule 1; Kim1; KIM-1; T cell immunoglobin domain and mucin domain protein 1; t cell immunoglobulin and mucin domain-containing protein 1; T cell membrane protein 1; T-cell immunoglobulin and mucin domain containing 1; T-cell immunoglobulin and mucin domain-containing protein 1; T-cell immunoglobulin mucin family member 1; T-cell immunoglobulin mucin receptor 1; T-cell membrane protein 1; TIM; TIM1; TIM-1; TIMD1; TIMD-1