This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
HCN2 Monoclonal Antibody (S71)
catalog :
MA5-27718
quantity :
100 ug
price :
US 504.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
S71

The same clone is also sold as:
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 1
Reference
Kwon J, Choi Y, Jo H, Lee S, Lee H, Kim H, et al. The Role of Prostaglandin E1 as a Pain Mediator through Facilitation of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channel 2 via the EP2 Receptor in Trigeminal Ganglion Neurons of Mice. Int J Mol Sci. 2021;22: pubmed publisher
product information
Product Type :
Antibody
Product Name :
HCN2 Monoclonal Antibody (S71)
Catalog # :
MA5-27718
Quantity :
100 ug
Price :
US 504.00
Clonality :
Monoclonal
Purity :
Protein G
Host :
Mouse
Reactivity :
Mouse, Rat
Applications :
Antibody Microarray: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:1,000, Immunohistochemistry (Paraffin): 1:1,000, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000
Species :
Mouse, Rat
Clone :
S71
Isotype :
IgG1
Storage :
-20 C
Description :
Hyperpolarization-activated cation channels of the HCN gene family such as HCN2, contribute to spontaneous rhythmic activity in both heart and brain. HCN2 is a member of a family of pacemaker channels activated by hyperpolarization and regulated by cyclic nucleotides. HCN1 and HCN2 play an important role for motor learning and neuronal integration by cerebellar Purkinje cells; as well as, shaping autonomous activity of single neurons and the periodicity of network oscillations. The HCN1 expression is highly enriched in cerebral cortex, hippocampus, cerebellum, and facial motor nucleus. HCN2 is highly abundant in mamillary bodies, pontine nucleus, ventral cochlear nucleus, and nucleus of the trapezoid body. These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems.
Immunogen :
Fusion protein amino acids 761-863 of rat HCN2
Format :
Liquid
Applications w/Dilutions :
Antibody Microarray: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (Frozen): 1:1,000, Immunohistochemistry (Paraffin): 1:1,000, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000
Aliases :
BCNG2; BCNG-2; brain cyclic nucleotide gated channel 2; brain cyclic nucleotide-gated channel 2; Hac1; HAC-1; HCN2; hyperpolarization activated cyclic nucleotide gated potassium channel 2; hyperpolarization activated cyclic nucleotide-gated potassium channel 2; hyperpolarization-activated cation channel 1; hyperpolarization-activated, cyclic nucleotide-gated K+ 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; trls
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA