SHANK2 Monoclonal Antibody (N23b/6) | Invitrogen MA5-27634 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SHANK2 Monoclonal Antibody (N23b/6)

catalog :

MA5-27634

quantity :

100 µg

price :

US 486.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

N23B/6

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 1

Reference
Modi M, Brooks J, Guilmette E, Beyna M, Graf R, Reim D, et al. Hyperactivity and Hypermotivation Associated With Increased Striatal mGluR1 Signaling in a Shank2 Rat Model of Autism. Front Mol Neurosci. 2018;11:107 pubmed publisher

product information

Product Type :

Antibody

Product Name :

SHANK2 Monoclonal Antibody (N23b/6)

Catalog # :

MA5-27634

Quantity :

100 µg

Price :

US 486.00

Clonality :

Monoclonal

Purity :

Protein G

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Antibody Microarray: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (PFA fixed): 1:100, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000

Species :

Human, Mouse, Rat

Clone :

N23b/6

Isotype :

IgG1

Storage :

-20°C

Description :

This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants.

Immunogen :

Fusion protein amino acids 84-309 (SH3/PDZ domains) of rat Shank2 (SH3 and multiple ankyrin repeat domains protein 2)

Format :

Liquid

Applications w/Dilutions :

Antibody Microarray: Assay-dependent, Immunocytochemistry: 1:100, Immunohistochemistry (PFA fixed): 1:100, Immunoprecipitation: Assay-Dependent, Western Blot: 1:1,000

Aliases :

AUTS17; cortactin SH3 domain-binding protein; cortactin-binding protein 1; CortBP1; CORTBP1CTTNBP1; CTTNBP1; GKAP/SAPAP interacting protein; GKAP/SAPAP-interacting protein; Kiaa1022; mKIAA1022; proline rich synapse associated protein 1; proline-rich synapse associated protein 1; proline-rich synapse-associated protein 1; PROSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SH3/ankyrin domain gene 2; SHANK; Shank2; SPANK-3