SIRT1 Monoclonal Antibody (OTI5B2) | Invitrogen MA5-27217 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

SIRT1 Monoclonal Antibody (OTI5B2)

catalog :

MA5-27217

quantity :

100 uL

price :

US 542.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OTI5B2

The same clone is also sold as:

OriGene: TA809834, CF809834, TA809834S, TA809834BM, TA809834AM

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 1

Reference
Orhan C, Sahin E, Tuzcu M, Sahin N, Celik A, Ojalvo S, et al. Nicotinamide Riboside and Phycocyanin Oligopeptides Affect Stress Susceptibility in Chronic Corticosterone-Exposed Rats. Antioxidants (Basel). 2023;12: pubmed publisher

product information

Product Type :

Antibody

Product Name :

SIRT1 Monoclonal Antibody (OTI5B2)

Catalog # :

MA5-27217

Quantity :

100 uL

Price :

US 542.00

Clonality :

Monoclonal

Purity :

Affinity Chromatography

Host :

Mouse

Reactivity :

Human, Mouse, Rat

Applications :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:2,000, Western Blot: 1:500-1:2,000

Species :

Human, Mouse, Rat

Clone :

OTI5B2

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

NAD-dependent protein deacetylase sirtuin-1 (SIRT1) links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, repsonse to DNA damage, metabolism, apoptosis, and autophagy. SIRT1 can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histone and DNA, leading to transcriptional repression. It is essential in skeletal muscle cell differentiation and in response to low nutrients mediates the inhibitory effect on skeletal myoblast differentiation which also involves 5'-AMP-activated protein kinase (AMPK) and nicotinamide phosphoribosyltransferase (NAMPT).

Immunogen :

Human recombinant protein fragment corresponding to amino acids 552-676 of SIRT1 produced in E.coli

Format :

Liquid

Applications w/Dilutions :

Immunocytochemistry: 1:100, Immunohistochemistry (Paraffin): 1:2,000, Western Blot: 1:500-1:2,000

Aliases :

75SirT1; AA673258; hSIR2; hSIRT1; mSIR2a; NAD-dependent deacetylase sirtuin-1; NAD-dependent protein deacetylase sirtuin-1; OTTHUMP00000198111; OTTHUMP00000198112; Regulatory protein SIR2 homolog 1; RP11-57G10.3; SIR2; Sir2a; SIR2alpha; SIR2L1; sir2-like 1; SIR2-like protein 1; SIRT 1; SIRT1; SIRT-1; SirtT1 75 kDa fragment; sirtuin 1; sirtuin 1 ((silent mating type information regulation 2, homolog) 1; sirtuin type 1