HIST1H2BA Monoclonal Antibody (OTI1C9) | Invitrogen MA5-26966 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

HIST1H2BA Monoclonal Antibody (OTI1C9)

catalog :

MA5-26966

quantity :

100 uL

price :

US 514.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OTI1C9

The same clone is also sold as:

OriGene: TA808271BM, TA808271S, CF808271, TA808271, TA808271AM

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

HIST1H2BA Monoclonal Antibody (OTI1C9)

Catalog # :

MA5-26966

Quantity :

100 uL

Price :

US 514.00

Clonality :

Monoclonal

Purity :

Affinity Chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2,000

Species :

Human

Clone :

OTI1C9

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

Variant histone specifically required to direct the transformation of dissociating nucleosomes to protamine in male germ cells. Entirely replaces classical histone H2B prior nucleosome to protamine transition and probably acts as a nucleosome dissociating factor that creates a more dynamic chromatin, facilitating the large-scale exchange of histones. Also expressed maternally and is present in the female pronucleus, suggesting a similar role in protamine replacement by nucleosomes at fertilization. Also found in fat cells, its function and the presence of post-translational modifications specific to such cells are still unclear. Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.

Immunogen :

Human recombinant protein fragment corresponding to amino acids 2-127 of HIST1H2BA produced in E.coli

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2,000

Aliases :

bA317E16.3; H2B histone family, member U, (testis-specific); H2BFU; HIST1H2BA; histone 1, H2ba; histone cluster 1, H2ba; histone H2B type 1-A; Histone H2B, testis; STBP; testis-specific histone H2B; TH2B; TSH2B; TSH2B.1; TSH2B1