This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Invitrogen
other brands :
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
product type :
antibody
product name :
ROS1 Monoclonal Antibody (OTI1A1)
catalog :
MA5-26760
quantity :
100 uL
price :
US 510.00
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OTI1A1

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 2
Reference
Park H, Hoffman J, Brown M, Bheri S, Brazhkina O, Son Y, et al. Knockdown of deleterious miRNA in progenitor cell-derived small extracellular vesicles enhances tissue repair in myocardial infarction. Sci Adv. 2023;9:eabo4616 pubmed publisher
Deland L, Keane S, Bontell T, Fagman H, Sj xf6 gren H, Lind A, et al. Novel TPR::ROS1 Fusion Gene Activates MAPK, PI3K and JAK/STAT Signaling in an Infant-type Pediatric Glioma. Cancer Genomics Proteomics. 2022;19:711-726 pubmed publisher
product information
Product Type :
Antibody
Product Name :
ROS1 Monoclonal Antibody (OTI1A1)
Catalog # :
MA5-26760
Quantity :
100 uL
Price :
US 510.00
Clonality :
Monoclonal
Purity :
Affinity Chromatography
Host :
Mouse
Reactivity :
Human, Mouse
Applications :
Immunocytochemistry: 1:5,000-1:10,000, Immunohistochemistry (Paraffin): 1:500, Western Blot: 1:1,000
Species :
Human, Mouse
Clone :
OTI1A1
Isotype :
IgG2a
Storage :
-20 C, Avoid Freeze/Thaw Cycles
Description :
ROS1 is a tyrosine kinase that functions as a growth or differentiation factor receptor. Protein kinases are enzymes that transfer a phosphate group from a phosphate donor, generally the g phosphate of ATP, onto an acceptor amino acid in a substrate protein. By this basic mechanism, protein kinases mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. The tyrosine kinase (TK) group is mainly involved in the regulation of cell-cell interactions such as differentiation, adhesion, motility and death. There are currently about 90 TK genes sequenced, 58 are of receptor protein TK (e.g. EGFR, EPH, FGFR, PDGFR, TRK, and VEGFR families), and 32 of cytosolic TK (e.g. ABL, FAK, JAK, and SRC families).
Immunogen :
Human recombinant protein fragment corresponding to amino acids 1882-2125 of ROS1 produced in E.coli
Format :
Liquid
Applications w/Dilutions :
Immunocytochemistry: 1:5,000-1:10,000, Immunohistochemistry (Paraffin): 1:500, Western Blot: 1:1,000
Aliases :
c-ros; c-ros oncogene 1 , receptor tyrosine kinase; c-Ros receptor tyrosine kinase; c-ros-1; heart - derived c - ros - 1 proto - oncogene; MCF3; Proto-oncogene c-Ros; proto-oncogene c-Ros-1; Proto-oncogene tyrosine-protein kinase ROS; receptor tyrosine kinase c-ros oncogene 1; ROS; ROS proto-oncogene 1 , receptor tyrosine kinase; ROS proto-oncogene 1, receptor tyrosine kinase; Ros1; Ros-1; Ros1 proto-oncogene; ROS1C; RP1-179P9.1; transmembrane tyrosine-specific protein kinase; v-ros avian UR2 sarcoma virus oncogene homolog 1; v-ros UR2 sarcoma virus oncogene homolog 1
company information
Invitrogen
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com
800-678-5599
headquarters: USA