TLK2 Monoclonal Antibody (OTI2G1) | Invitrogen MA5-26736 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Invitrogen

other brands :

NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience

product type :

antibody

product name :

TLK2 Monoclonal Antibody (OTI2G1)

catalog :

MA5-26736

quantity :

100 uL

price :

US 504.00

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

OTI2G1

The same clone is also sold as:

OriGene: TA805458BM, TA805458S, CF805458, TA805458AM, TA805458

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

product information

Product Type :

Antibody

Product Name :

TLK2 Monoclonal Antibody (OTI2G1)

Catalog # :

MA5-26736

Quantity :

100 uL

Price :

US 504.00

Clonality :

Monoclonal

Purity :

Affinity Chromatography

Host :

Mouse

Reactivity :

Human

Applications :

Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2,000

Species :

Human

Clone :

OTI2G1

Isotype :

IgG1

Storage :

-20 C, Avoid Freeze/Thaw Cycles

Description :

TLK2 or Tousled-like kinase 2, is a nuclear serine/threonine kinases that is thought to be involved in the regulation of chromatin assembly. In addition, TLK2 is also involved in other cellular processes such as intracellular signaling cascade, protein amino acid phosphorylation, cell cycle, chromatin modification and in response to DNA damage stimulus. TLK2 displays maximal activity during S phase of the cell cycle where it appears to be regulated by cell-cycle-dependent phosphorylation. Inhibition of DNA replication causes a rapid loss of TLK2 activity, indicating that TLK2 function is tightly linked to ongoing DNA replication. The TLK2 enzyme is cell-cycle regulated, with maximal activity in S-phase. It is inactivated by phosphorylation at Ser-750, potentially by CHK1. TLK2 heterodimerizes with TLK1. This nuclear protein is widely expressed, with presence in fetal placenta, liver, kidney, pancreas, heart and skeletal muscle tissues, and in several adult cell lines.

Immunogen :

Human recombinant protein fragment corresponding to amino acids 1-296 of TLK2 produced in E.coli

Format :

Liquid

Applications w/Dilutions :

Immunohistochemistry (Paraffin): 1:150, Western Blot: 1:2,000

Aliases :

4933403M19Rik; HsHPK; PKUalpha; PKU-alpha; protein kinase U-alpha; serine/threonine-protein kinase tousled-like 2; Tlk; Tlk2; tousled like kinase 2; tousled-like kinase 2; tousled-like kinase 2 (Arabidopsis)